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Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

Lavogiez C.a · Delaporte E.a · Darras-Vercambre S.a · Martin De Lassalle E.b · Castillo C.b · Mirabel X.d · Laurent F.c · Patenotre P.c · Gheit T.e · Talmant J.C.f · Beylot-Barry M.g · Martinot V.c · Piette F.a · Aubin F.h · Mortier L.a
aUniversité de Lille 2 et Clinique de Dermatologie, bService d’Anatomie Pathologique et cService de Chirurgie Plastique et Réparatrice, CHRU de Lille, et dService de Radiothérapie, Centre Oscar Lambret, Lille, eInternational Agency for Research on Cancer, Lyon, fService de Chirurgie Plastique et Réparatrice, CHU de Strasbourg, Strasbourg, gService de Dermatologie, CHU de Bordeaux, Bordeaux, et hCHU de Besançon, Université de Franche-Comté, Besançon, France Dermatology 2010;220:147–153 (DOI:10.1159/000269836)

Abstract

Background: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases. Methods: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material. Results: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16. Conclusion: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.

 

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