Objectives: The authors compared the efficacies and tolerabilities of pegylated interferon-α2a (PEG-IFN-α2a) + ribavirin and pegylated interferon-α2b (PEG-IFN-α2b) + ribavirin for the initial treatment of chronic hepatitis C. Methods: A total of 126 treatment-naive patients (29.4% genotype 1, 70.6% genotype non-1) were treated with PEG-IFN-α2a 180 µg/week (group A, n = 79) or PEG-IFN-α2b 1.5 µg/kg/week (group B, n = 47) with ribavirin (800 mg/day for genotype non-1 or 1,000–1,200 mg/day for genotype 1) for 24 (genotype non-1) or 48 weeks (genotype 1). Results: End-of-treatment virologic response, sustained virologic response, and biochemical response were not significantly different in groups A and B (84.8 vs. 89.4%, 70.9 vs. 72.3%, and 70.9 vs. 74.5%, respectively; p > 0.05). In patients with the HCV genotype 1 or non-1, treatment responses were not significantly different. Multivariate analysis showed that HCV genotype only was an independent factor that affected sustained virologic response (p = 0.048). The proportions of treatment discontinuations in groups A and B were similar (10.1 vs. 10.6%; p = 1.000). Conclusions: PEG-IFN-α2a or PEG-IFN-α2b + ribavirin combination therapies showed similar efficacies and tolerabilities as initial treatments for chronic hepatitis C.
© 2010 S. Karger AG, Basel
- Chronic hepatitis C
- Pegylated interferon-α2a
- Pegylated interferon-α2b
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In Hee Kim, MD
Department of Internal Medicine, Research Institute of Clinical Medicine
Chonbuk National University Medical School and Hospital
634-18 Keumam-dong, Dukjin-ku, Jeonju, Jeonbuk 561-712 (South Korea)
Tel. +82 63 250 1677, Fax +82 63 254 1609, E-Mail firstname.lastname@example.org
Received: August 5, 2009
Accepted after revision: October 20, 2009
Published online: January 13, 2010
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 20
Intervirology (International Journal of Basic and Medical Virology)
Vol. 53, No. 3, Year 2010 (Cover Date: April 2010)
Journal Editor: Liebert U.G. (Leipzig)
ISSN: 0300-5526 (Print), eISSN: 1423-0100 (Online)
For additional information: http://www.karger.com/INT
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