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Effective Treatment with Topical Cyclosporin A of a Patient with Cogan Syndrome

Shimura M. · Yasuda K. · Fuse N. · Nakazawa M. · Tamai M.
Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Miyagi, Japan Ophthalmologica 2000;214:429–432 (DOI:10.1159/000027538)


The purpose of this report is to describe the effective treatment of severe anterior segment inflammation due to Cogan syndrome through the use of topical administration of cyclosporin A. A 47-year-old female patient had been experiencing headaches and difficulties with her vision. Subsequent examination revealed the sudden onset of bilateral conjunctival injection and swelling of bilateral auricles. Despite the multiple treatment (systemic and topical corticosteroid and antibiotic therapy), necrotizing scleritis had appeared bilaterally and the scleral wall was thinning. Topical administration of 1% cyclosporin A was applied to both eyes 4 times a day. After 2 months of this therapy, the epithelial tissue covered the necrotizing tissue and her symptom of ocular pain was relieved and her corrected visual acuity was improved. This is the first case exhibiting that topical cyclosporin A is an effective treatment for severe anterior segment inflammation associated with Cogan syndrome.

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