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Hyalinizing Clear Cell Carcinoma of the Oral Cavity and of the Parotid Gland

Rinaldo A.a · McLaren K.M.b · Boccato P.c · Maran A.G.D.a
aDepartment of Otolaryngology, City Hospital, Royal Infirmary of Edinburgh, and bDepartment of Pathology, University of Edinburgh, UK; cCytopathology Laboratory, Arcella Analisi Mediche, Padua, Italy ORL 1999;61:48–51 (DOI:10.1159/000027639)


Hyalinizing clear cell carcinoma (HCCC) is a rare, recently described tumor of salivary gland origin. Differential diagnosis includes benign lesions as clear cell change in a pleomorphic adenoma or in oncocytoma and malignant tumors – i.e. epithelial-myoepithelial carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, clear cell acinic carcinoma, clear cell squamous carcinoma, clear cell malignant melanoma, clear cell odontogenic carcinoma, clear cell rhabdomyosarcoma, sebaceous carcinoma and metastasis of renal carcinoma. A favorable prognosis after wide local excision has been evidenced. Three new cases of HCCC (2 in the oral cavity and 1 in the parotid gland) are presented.


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