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Vol. 29, No. 4, 2010
Issue release date: May 2010
Section title: Original Research Article
Dement Geriatr Cogn Disord 2010;29:371–378
(DOI:10.1159/000278692)

Clinical Features of Rapidly Progressive Alzheimer’s Disease

Schmidt C. · Redyk K. · Meissner B. · Krack L. · von Ahsen N. · Roeber S. · Kretzschmar H. · Zerr I.
Departments of aNeurology and bClinical Chemistry, Hospital of the Georg August University Goettingen, Goettingen, and cDepartment of Neuropathology, Hospital of the Ludwig Maximilian University Munich, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 1/19/2010
Published online: 5/5/2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer’s dementia (rpAD). Methods: Retrospective analyses of 32 neuropathologically confirmed cases differentially diagnosed as AD out of a group with rapidly progressive dementia. CSF biomarkers (14-3-3, tau, β-amyloid 1–42) and genetic markers (PRNP codon 129, apolipoprotein E, ApoE, polymorphism) were determined. Results: Median survival was 26 months, age at onset 73 years. Biomarkers: mean β-amyloid 1–42: 266 pg/ml, median tau: 491 pg/ml, 14-3-3 positive: 31%. Genetic polymorphisms showed a predominance of methionine homozygosity at PRNP codon 129 and a low frequency of ApoE4 (38%, no homozygous patients). Thirty-five symptoms were studied. Frequent symptoms were myoclonus (75%), disturbed gait (66%) and rigidity (50%). Discussion: rpAD is associated with a diversity of neurological signs even able to mimic Creutzfeldt-Jakob disease. Biomarkers and genetic profile differ from those seen in classical AD. The findings on biomarkers, symptomatology and genetics may aid the differential diagnostic process.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 1/19/2010
Published online: 5/5/2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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