Linear IgA Disease: Successful Application of Immunoadsorption and Review of the LiteratureKasperkiewicz M. · Meier M. · Zillikens D. · Schmidt E.
Departments of aDermatology and bInternal Medicine, University of Lübeck, Lübeck, Germany
Linear IgA disease (LAD) is an autoimmune subepidermal blistering disorder characterized by IgA autoantibodies at the dermal-epidermal junction. Conventional first-line treatments include dapsone with or without oral glucocorticosteroids. Various other therapeutic approaches have been used in refractory patients. Immunoadsorption (IA) has been previously successfully applied in severe and/or otherwise treatment-resistant IgG-mediated immunobullous disorders. Here, we report a patient with a severe generalized LAD in whom adjuvant tryptophan IA was associated with rapid healing of skin lesions. Our observation suggests that IA may also be a helpful adjuvant treatment option for severe LAD.
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