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Vol. 34, No. 3, 2010
Issue release date: April 2010
Section title: Review
Neuroepidemiology 2010;34:171–183
(DOI:10.1159/000279334)

The Incidence of Myasthenia Gravis: A Systematic Literature Review

McGrogan A. · Sneddon S. · de Vries C.S.
aDepartment of Pharmacy and Pharmacology, University of Bath, Bath, and bDepartment of Pharmacoepidemiology, Postgraduate Medical School, University of Surrey, Guildford, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/4/2009
Accepted: 12/7/2009
Published online: 2/2/2010

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: A systematic review of literature published between 1980 and 2007, on the incidence of myasthenia gravis, was undertaken. Methods: All relevant papers found through searches of Medline, Embase and Science Direct were critically appraised and an assessment was made of the reliability of the reported incidence data. Results: Thirty-one studies were included in the review, the majority of which investigated populations in Europe. The incidence rates reported were between 3.0 and 30.0/1,000,000/year. However, it is thought that the rates at the upper end of this range, reported by the prospective studies, provided the most accurate estimates. Overall, incidence rates have increased over time owing to a greater awareness of the disease and improved methods of diagnosis. Conclusions: The most accurate estimate of incidence of myasthenia gravis was around 30/ 1,000,000/year. The incidence in children and adolescents aged 0–19 years was found to be between 1.0 and 5.0/ 1,000,000/year. The rates presented in this review are likely to be an underestimate of the true incidence rates, as mild cases will have been missed and cases in the elderly will have been misdiagnosed.


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/4/2009
Accepted: 12/7/2009
Published online: 2/2/2010

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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