Background: Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. Objectives: To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants. Methods: Randomised controlled trials (RCTs) of postnatal hydrocortisone therapy to prevent or treat BPD were sought. Data regarding clinical outcomes including mortality, BPD, death or BPD, complications during the primary hospitalisation, and long-term outcome were abstracted and analysed using RevMan 5. Results: Eight RCTs enrolling a total of 880 participants were eligible. In all trials treatment was started in the first week of life; there were no trials of treatment started in infants who were chronically ventilator-dependent after the first week of life with established or evolving BPD. A meta-analysis of the available trials demonstrated little evidence for a direct effect of hydrocortisone on the rates of BPD, mortality, or the combined outcome of BPD or mortality. Hydrocortisone in the doses used in these eight studies had few beneficial or harmful effects; the notable exception was an increase in gastrointestinal perforation. Conclusions: Postnatal hydrocortisone in the doses and regimens used in the reported trials has few beneficial or harmful effects and cannot be recommended for prevention of BPD. There are no randomised trials to substantiate the use of hydrocortisone in chronically ventilator-dependent infants with established or evolving BPD.
© 2010 S. Karger AG, Basel
- Bronchopulmonary dysplasia
- Bronchopulmonary dysplasia treatment, infants
- Mortality rate
- Cerebral palsy
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Prof. Lex W. Doyle
Department of Obstetrics and Gynaecology, The Royal Women’s Hospital
20 Flemington Rd
Parkville, Vic. 3052 (Australia)
Tel. +61 3 8345 3716, Fax +61 3 8345 3702, E-Mail firstname.lastname@example.org
Supported in part by Project Grant No. 108700 from the National Health and Medical Research Council, Australia.
Published online: February 12, 2010
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 30
Neonatology (Fetal and Neonatal Research)
Vol. 98, No. 2, Year 2010 (Cover Date: August 2010)
Journal Editor: Halliday H.L. (Belfast), Speer C.P. (Würzburg)
ISSN: 1661-7800 (Print), eISSN: 1661-7819 (Online)
For additional information: http://www.karger.com/NEO
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