Cover

Importance of Growth for Health and Development

65th Nestlé Nutrition Institute Workshop, Pediatric Program, Kuala Lumpur, March 2009

Editor(s): Lucas A. (London) 
Makrides M. (Adelaide, S.A.) 
Ziegler E.E. (Iowa City, Iowa) 
Table of Contents
Vol. 65, No. , 2010
Section title: Growth and Neurological Development
Lucas A, Makrides M, Ziegler EE (eds): Importance of Growth for Health and Development. Nestlé Nutr Inst Workshop Ser Pediatr Program, vol 65, pp 123–136, Nestec Ltd., Vevey/S. Karger AG, Basel, © 2010
(DOI:10.1159/000281154)

Role of Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment and Growth

Makrides M. · Smithers L.G. · Gibson R.A.
Women’s and Children’s Health Research Institute and University of Adelaide, S.A., Australia

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Article / Publication Details

First-Page Preview
Abstract of Growth and Neurological Development

Published online: 2/1/2010
Cover Date: 2010

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9304-5 (Print)
eISBN: 978-3-8055-9305-2 (Online)

Abstract

There has been intense interest in the role of the n-3 long-chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA, 22:6n-3), in growth and development of infants. In 2009, there are at least twelve published randomized controlled trials (RCT) assessing the effects of LCPUFA supplementation of infant formula for preterm infants and seventeen RCTs involving formula-fed term infants. In addition, at least five RCTs have investigated the effect of DHA supplementation during pregnancy and/or lactation on infant and early child development. Collectively, the published literature has demonstrated no harm of dietary LCPUFA for infants regardless of whether they are born preterm or at term. However, developmental benefit is more consistently observed in infants born preterm. This may be explained by the fact that DHA accretion to neural tissues peaks during the fetal brain growth spurt in the last trimester of pregnancy. Infants born preterm are denied the full gestation period to accumulate DHA and are at risk of incomplete DHA accumulation. New research is focused on the timing and dose of DHA supplementation needed to optimize developmental outcomes.


Article / Publication Details

First-Page Preview
Abstract of Growth and Neurological Development

Published online: 2/1/2010
Cover Date: 2010

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9304-5 (Print)
eISBN: 978-3-8055-9305-2 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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