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Table of Contents
Vol. 28, No. 1, 1995
Issue release date: 1995
Psychopathology 1995;28:18–21

Brain Changes and Negative Symptoms in Schizophrenia

Crow T.J.
University Department of Psychiatry, Warneford Hospital, Oxford, UK

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Negative symptoms (and cognitive impairments) in schizophrenia are a correlate of early onset and poor outcome. It is plausible that they are related to an arrest of brain development, for which there is now considerable evidence, but the precise relationship is elusive. In one post-mortem study negative symptoms were related to a reduction in brain length and in an MRI study to an asymmetry of sulcal CSF. It is proposed that the phenomena of psychosis (including negative symptoms) can be understood as part of the diversity of human personality structure generated by a process of sexual selection acting on a sexual dimorphism for cerebral asymmetry.

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