Vol. 7, No. 1-3, 2010
Issue release date: April 2010
Free Access
Neurodegenerative Dis 2010;7:68–75
(DOI:10.1159/000285509)
Biology of Neurodegeneration
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LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins

Hsu C.H.a · Chan D.a · Wolozin B.a, b
Departments of aPharmacology and bNeurology, Boston University School of Medicine, Boston, Mass., USA
email Corresponding Author


 goto top of outline Key Words

  • MAP kinase
  • c-jun NH2-terminal kinase
  • Scaffold proteins
  • Parkinson’s disease
  • Immunoprecipitation

 goto top of outline Abstract

Increasing evidence supports a putative link between LRRK2 function and the MAP kinase cascades. We recently demonstrated that LRRK2 binds to MKK6, -3, and -7. Previous studies demonstrated that scaffold proteins are essential in the regulation of subcellular localization of stress kinase complexes. The c-jun NH2-terminal kinase (JNK)-interacting proteins (JIPs) are a group of scaffold proteins that play an important role in the regulation of MAP kinase signaling cascades. JIP1–3 are known to regulate the specificity and localization of the JNK pathway, while JIP4 is a specific scaffolding protein for the p38 pathway. We demonstrate that LRRK2 binds to JIP1–4, and is associated with increased levels of total JIP1, -3, -4, oligomeric JIP and ubiquitinated JIP. These results are consistent with a putative role of LRRK2 in regulating the stress kinase cascade.

Copyright © 2010 S. Karger AG, Basel


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 goto top of outline Author Contacts

Benjamin Wolozin
Departments of Pharmacology and Neurology, Boston University School of Medicine
72 East Concord St., R614
Boston, MA 02118-2526 (USA)
Tel. +1 617 414 2652, Fax +1 617 414 2651, E-Mail bwolozin@bu.edu


 goto top of outline Article Information

Published online: February 18, 2010
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 0, Number of References : 38


 goto top of outline Publication Details

Neurodegenerative Diseases

Vol. 7, No. 1-3, Year 2010 (Cover Date: April 2010)

Journal Editor: Nitsch R.M. (Zürich), Hock C. (Zürich)
ISSN: 1660-2854 (Print), eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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