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Vol. 7, No. 1-3, 2010
Issue release date: April 2010
Neurodegenerative Dis 2010;7:148–152

Human Analogue of the Morris Water Maze for Testing Subjects at Risk of Alzheimer’s Disease

Laczó J. · Andel R. · Vyhnalek M. · Vlcek K. · Magerova H. · Varjassyova A. · Tolar M. · Hort J.
aDepartment of Neurology, Charles University, and bDepartment of Neurophysiology of Memory, Czech Academy of Sciences, Prague, Czech Republic; cSchool of Aging Studies, University of South Florida, Tampa, Fla., and dDepartment of Neurology, Yale University School of Medicine, New Haven, Conn., USA

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Background: Patients with Alzheimer’s disease (AD) and amnestic mild cognitive impairment (MCI) have difficulties with spatial orientation. Objective: To test hypothesis that spatial navigation is impaired early in MCI patients representing the presymptomatic stage of AD. Methods: We tested patients with probable AD (n = 21), MCI, further classified according to Petersen’s criteria as amnestic MCI (aMCI) single domain (n = 11), aMCI multiple domain (n = 31), or nonamnestic MCI (n = 7). The aMCI group was also stratified using cued recall according to Dubois’ criteria into memory impairment of the hippocampal type (n = 10) and isolated memory retrieval impairment-nonhippocampal (n = 32) and also according to ApoE4 status into E4+ (n = 12) and E4– (n = 30). These patients and controls (n = 28) were tested in the human variant of the Morris water maze. Depending on the subtest, the subjects could use the egocentric or allocentric (hippocampus-dependent) navigation. Results: The AD and aMCI multiple domain groups were impaired in all subtests. The aMCI single domain group was impaired in allocentric subtests. The hippocampal MCI group performed poorer than the nonhippocampal MCI group and similarly to the AD group. The ApoE4+ group was as bad as the AD group when compared with the E4– group. Conclusion: aMCI subjects represent a very heterogeneous population, and spatial memory or cued recall examination can add more value to aMCI classification. ApoE4+ patients are more impaired than ApoE4– patients.

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  1. Mapstone M, Steffenella TM, Duffy CJ: A visuospatial variant of mild cognitive impairment: getting lost between aging and AD. Neurology 2003;60:802–808.
  2. Monacelli AM, Cushman LA, Kavcic V, Duffy CJ: Spatial disorientation in Alzheimer’s disease: the remembrance of things passed. Neurology 2003;61:1491–1497.
  3. Kalova E, Vlcek K, Jarolimova E, Bures J: Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer’s disease: corresponding results in real space tests and computer tests. Behav Brain Res 2005;159:175–186.
  4. Petersen RC: Mild cognitive impairment as a diagnostic entity. J Intern Med 2004;256:183–194.
  5. Dubois B, Albert ML: Amnestic MCI or prodromal Alzheimer’s disease? Lancet Neurol 2004;3:246–248.
  6. Raber J, Wong D, Yu G-Q, Buttini M, Mahley RW, Pitas RE, Mucke L: Alzheimer’s disease: apolipoprotein E and cognitive performance. Nature 2000;404:352–354.
  7. Hort J, Laczó J, Vyhnálek M, Bojar M, Bures J, Vlcek K: Spatial navigation deficit in amnestic mild cognitive impairment. Proc Natl Acad Sci USA 2007;104:4042–4047.
  8. Laczó J, Andel R, Vlček K, Macoška V, Vyhnálek M, Tolar M, Bojar M, Hort J: Spatial navigation and APOE in amnestic mild cognitive impairment. Submitted to Neurology.

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