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Vol. 33, No. 2, 2000
Issue release date: August 2000
Pediatr Neurosurg 2000;33:76–82

Age-Related Differences in Acute Physiologic Response to Focal Traumatic Brain Injury in Piglets

Durham S.R. · Raghupathi R. · Helfaer M.A. · Marwaha S. · Duhaime A.-C.
aDepartment of Neurosurgery, University of Pennsylvania School of Medicine, bDivision of Neurosurgery, The Children’s Hospital of Philadelphia, and cDepartment of Anesthesia/Critical Care Medicine, The Children’s Hospital of Philadelphia, Pa., USA

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Introduction: The goal of the present study was to determine whether age-related differences in the acute physiologic response to scaled cortical impact injury contribute to differences in vulnerability to traumatic brain injury (TBI). Methods: Heart rate (HR), mean arterial pressure (MAP), brain temperature (BrT) and cerebral blood flow (CBF) were measured in 22 piglets (7 of age 5 days, 8 of age 1 month, 7 of age 4 months) at baseline and for 3 h following scaled cortical impact injury. Results: There were no age-dependent variations from baseline in HR, MAP or BrT following injury. CBF increased in the 5-day-old animals following injury while CBF in the 1- and 4-month-old animals decreased following injury (p = 0.0049). Conclusion: CBF was shown to have a significant age-dependent response to TBI with the youngest animals exhibiting increased CBF following injury.

Copyright © 2000 S. Karger AG, Basel

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