Journal Mobile Options
Table of Contents
Vol. 33, No. 2, 2000
Issue release date: August 2000

Age-Related Differences in Acute Physiologic Response to Focal Traumatic Brain Injury in Piglets

Durham S.R. · Raghupathi R. · Helfaer M.A. · Marwaha S. · Duhaime A.-C.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Introduction: The goal of the present study was to determine whether age-related differences in the acute physiologic response to scaled cortical impact injury contribute to differences in vulnerability to traumatic brain injury (TBI). Methods: Heart rate (HR), mean arterial pressure (MAP), brain temperature (BrT) and cerebral blood flow (CBF) were measured in 22 piglets (7 of age 5 days, 8 of age 1 month, 7 of age 4 months) at baseline and for 3 h following scaled cortical impact injury. Results: There were no age-dependent variations from baseline in HR, MAP or BrT following injury. CBF increased in the 5-day-old animals following injury while CBF in the 1- and 4-month-old animals decreased following injury (p = 0.0049). Conclusion: CBF was shown to have a significant age-dependent response to TBI with the youngest animals exhibiting increased CBF following injury.

Copyright © 2000 S. Karger AG, Basel



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Armstead W, Kurth C: Different cerebral hemodynamic responses following fluid percussion brain injury in the newborn and juvenile pig. J Neurotrauma 1994;11:487–497.
  2. Duhaime A, Margulies S, Durham S, O’Rourke M, Golden J, Marwaha S, Raghupathi R: Maturation-dependent response of the piglet brain to scaled cortical impact. J Neurosurg, in press.
  3. Bauer R, Walter B, Wurker E, Kluge H, Zwiener U: Colored microsphere technique as a new method for quantitative multiple estimation of regional hepatic and portal blood flow. Exp Toxic Pathol 1996;48:415–420.
  4. Bauer R, Walter B, Torossian A, Fritz H, Schonski O, Jochum T, Hoyer D, Reinhart K, Zwiener U: A piglet model for evaluation of cerebral blood flow and brain oxidative metabolism during gradual cerebral perfusion pressure decrease. Pediatr Neurosurg 1999;30:62–69.
  5. Walter B, Bauer R, Gaser E, Zwiener U: Validation of the multiple colored microsphere technique for regional blood flow measurements in newborn piglets. Basic Res Cardiol 1997;92:191–200.
  6. Chiron C, Raynaud C, Mazière B, Zilbovicius M, Laflamme L, Masure M, Dulac O, Bourguignon M, Syrota A: Changes in regional cerebral blood flow during brain maturation in children and adolescents. J Nucl Med 1992;33:696–703.
  7. Zwienenberg M, Muizelaar J: Severe pediatric head injury: The role of hyperemia revisited. J Neurotrauma 1999;16:937–943.
  8. Takahashi T, Shirane R, Sato S, Yoshimoto T: Developmental changes of cerebral blood flow and oxygen metabolism in children. AJNR 1999;20:917–922.
  9. Horiuchi I, Sanada S, Ohtahara S: Developmental and physiologic changes in cerebral blood flow velocity. Pediatr Res 1993;34:385–388.
  10. Kety S: Human cerebral blood flow and oxygen consumption as related to aging. J Chronic Dis 1956;3:478–486.
  11. Moller W, Wolschendorf K: The dependence of cerebral blood flow on age. Eur Neurol 1978;17:276–279.

    External Resources

  12. Bruce D, Alvai A, Bilaniuk L, Dolinskas C, Obrist W, Uzzell B: Diffuse cerebral swelling following head injuries in children: The syndrome of ‘malignant brain edema’. J Neurosurg 1981;54:170–178.
  13. Muizelaar J, Marmarou A, DeSalles A, Ward J, Zimmerman R, Li Z, Choi S, Young H: Cerebral blood flow and metabolism in severly head-injured children. 1. Relationship with GCS score, outcome, ICP, and PVI. J Neurosurg 1989;71:63–71.
  14. Sharples P, Stuart A, Matthews D, Aynsley-Green A, Eyre J: Cerebral blood flow and metabolism in children with severe head injury. 1. Relation to age, Glasgow Coma Score, outcome, intracranial pressure and time after injury. J Neurol Neurosurg Psychiatry 1995;58:145–152.
  15. Skippen P, Seear M, Poskitt K, Kestle J, Cochrane D, Annich G, Handel J: Effect of hyperventilation on regional cerebral blood flow in head-injured children. Crit Care Med 1997;25:1402–1409.
  16. Adelson P, Clyde B, Kochanek P, Wisniewski S, Marion D, Yonas H: Cerebrovascular response in infants and young children following severe traumatic brain injury: A preliminary report. Pediatr Neurosurg 1997;26:200–207.
  17. Grundle P, Biagas K, Kochanek P, Schiding J, Barmada M, Nemoto E: Early cerebrovascular response to head injury in immature and mature rats. J Neurotrauma 1994;11:135–148.
  18. Biagas K, Grundle P, Kochanek P, Schiding J, Nemoto E: Posttraumatic hyperemia in immature, mature and aged rats: Autoradiographic determination of cerebral blood flow. J Neurotrauma 1996;13:189–200.
  19. Ichord R, Kirsch J, Helfaer M, Haun S, Traystman R: Age-related differences in recovery of blood flow and metabolism after cerebral ischemia in swine. Stroke 1991;22:626–634.
  20. Kirsch J, Helfaer M, Blizzard K, Toung T, Traystman R: Age-related cerebrovascular response to global ischemia in pigs. Am J Physiol 1990;259:1551–1558.
  21. Cheng Y, Gidday J, Yan Q, Shah A, Holtzman D: Marked age-dependent neuroprotection by brain-derived neurotrophic factor again neonatal hypoxic-ischemic brain injury. Ann Neurol 1997;41:521–529.
  22. Bell M, Kochanek P, Doughty L, Carcillo J, Adelson P, Clark R, Wisniewski S, Whalen M, DeKosky S: Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 1997;14:451–457.
  23. Nagayama M, Aber T, Nagayama T, Ross M, Iadecola C: Age-dependent increase in ischemic brain injury in wild-type mice and in mice lacking the inducible nitric oxide synthase gene. J Cereb Blood Flow Metab 1999;19:661–666.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50