Background:Volatile anesthetics cause Alzheimer’s disease (AD)-like neuropathology in animals. We determined whether spine surgery under general anesthesia and anesthetic choice contributed to AD development. Methods: We searched the Clinical Data Repository of the University of Virginia for patients receiving spine surgery from January 1, 1992 to March 1, 2004. Patients with newly-diagnosed AD after the surgery but before March 1, 2009 (a minimal 5-year follow-up time after the surgery) were identified. Results: Among 10,161 spine surgery patients, 26 patients had new-onset AD. Univariate and multivariate logistic regression analyses of the data from these 26 patients and from 161 randomly selected spine surgery patients without new-onset AD suggest that increasing age is a risk factor for new-onset AD. Gender, anesthesia/surgery time, use of volatile anesthetics versus propofol (an intravenous anesthetic) and length of hospital stay were not different between patients with and without new-onset AD. Similar results were found with the case-control study. The frequency of new-onset AD in spine surgery patients was similar to that of patients who had never had a surgery. Conclusion: These results suggest that increasing age is a risk factor for AD in patients after spine surgery. Anesthesia/surgery may not be independent factors for AD development.
© 2010 S. Karger AG, Basel
- Alzheimer’s disease
- Spine surgery
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Prof. Zhiyi Zuo
Department of Anesthesiology, University of Virginia Health System
1 Hospital Drive, PO Box 800710
Charlottesville, VA 22908-0710 (USA)
Tel. +1 434 924 2283, Fax +1 434 924 2105, E-Mail email@example.com
Accepted: February 26, 2010
Published online: April 6, 2010
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 4, Number of References : 30
Dementia and Geriatric Cognitive Disorders
Vol. 29, No. 3, Year 2010 (Cover Date: April 2010)
Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)
For additional information: http://www.karger.com/DEM
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