Pathobiology 2010;77:210–217
(DOI:10.1159/000296305)

Dietary Linoleic Acid and Glucose Enhances Azoxymethane-Induced Colon Cancer and Metastases via the Expression of High-Mobility Group Box 1

Ohmori H. · Luo Y. · Fujii K. · Sasahira T. · Shimomoto T. · Denda A. · Kuniyasu H.
Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
email Corresponding Author


 goto top of outline Key Words

  • Azoxymethane
  • Colorectal cancer
  • HMGB1
  • Linoleic acid

 goto top of outline Abstract

Objective: High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer. Methods: We examined the significance of HMGB1 in causing colon carcinogenesis induced by azoxymethane (AOM) injection in Fischer 344 rats fed on a control diet (group C), a 15% linoleic acid (LA) diet (group L), a control diet with 10% glucose drink (group G), and a 15% LA diet with a 10% glucose drink (group L+G). Results: Group L+G showed the highest body weight and calorie intake. Serum and mucosal HMGB1 levels were temporally increased in all groups, while the highest levels were observed in group L+G. Mucosal HMGB1 levels were correlated with cancer multiplicity and nodal metastases. In the AOM-injected rats fed the 15% LA diet with 10% glucose drink, administration of HMGB1 antibody suppressed serum HMGB1 concentration and cancer multiplicity . Conclusion: These data suggest that dietary LA and glucose provided the synergistic effect on AOM-induced rat colon cancer through HMGB1 induction.

Copyright © 2010 S. Karger AG, Basel


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 goto top of outline Author Contacts

Dr. Hiroki Kuniyasu
Department of Molecular Pathology, Nara Medical University
840 Shijo-cho
Kashihara, Nara 634-8521 (Japan)
Tel. +81 74 422 3051, Fax +81 74 425 7308, E-Mail cooninh@zb4.so-net.ne.jp


 goto top of outline Article Information

Received: January 25, 2010
Accepted after revision: March 9, 2010
Published online: July 07, 2010
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 2, Number of References : 39


 goto top of outline Publication Details

Pathobiology (Exploring the basis of disease)

Vol. 77, No. 4, Year 2010 (Cover Date: July 2010)

Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015-2008 (Print), eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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