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Vol. 13, No. 3-4, 2000
Issue release date: May–August 2000
Skin Pharmacol Appl Skin Physiol 2000;13:157–164
(DOI:10.1159/000029921)

Use of Infrared Attenuated Total Reflectance Spectroscopy for the in vivo Measurement of Hydration Level and Silicone Distribution in the Stratum corneum following Skin Coverage by Polymeric Dressings

Branagan M. · Chenery D.H. · Nicholson S.
Smith and Nephew Group Research Centre, York Science Park, Heslington, York, UK

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Abstract

The ability of wound dressings to hydrate the stratum corneum has been tested experimentally using attenuated total reflectance (ATR) infrared spectroscopy. A silicone gel dressing was able to hydrate the stratum corneum to the extent that its water content within the sampled volume was >60% after 5 h of contact compared with about 15% of normal exposed skin and about 30% for a highly permeable hydrophilic polyurethane dressing. An ATR method was devised to determine the presence and depth of penetration of silicone in the stratum corneum as a result of skin coverage by the polymeric dressing.

Copyright © 2000 S. Karger AG, Basel



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