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Vol. 53, No. 5, 2010
Issue release date: June 2010
Section title: Paper
Free Access
Intervirology 2010;53:284–292

Origin and Evolution of Eukaryotic Large Nucleo-Cytoplasmic DNA Viruses

Koonin E.V. · Yutin N.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Md., USA
email Corresponding Author

Eugene V. Koonin

National Center for Biotechnology Information

National Library of Medicine, National Institutes of Health

Bethesda, MD 20894 (USA)



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  2. Forterre P: The origin of viruses and their possible roles in major evolutionary transitions. Virus Res 2006;117:5–16.
  3. Koonin EV, Senkevich TG, Dolja VV: The ancient virus world and evolution of cells. Biol Direct 2006;1:29.
  4. Iyer LM, Aravind L, Koonin EV: Common origin of four diverse families of large eukaryotic DNA viruses. J Virol 2001;75:11720–11734.
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    External Resources
  16. Boyer M, Yutin N, Pagnier I, Barrassi L, Fournous G, Espinosa M, Robert C, Azza A, Sun S, Rossmann MG, Suzan-Monti M, La Scola B, Koonin EV, Raoult D: Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimaeric microorganisms. Proc Natl Acad Sci USA 2009;106:21848–21853.
  17. Koonin EV: Comparative genomics, minimal gene-sets and the last universal common ancestor. Nat Rev Microbiol 2003;1:127–136.
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  29. Yutin N, Koonin EV: Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity. Biol Direct 2009;4:51.
  30. Paran N, De Silva FS, Senkevich TG, Moss B: Recruitment of cellular DNA ligase I to cytoplasmic vaccinia virus factories complements viral DNA replication in the absence of the viral ligase. Cell Host Microbe 2009;6:563–569.
  31. Claverie JM, Grzela R, Lartigue A, Bernadac A, Nitsche S, Vacelet J, Ogata H, Abergel C: Mimivirus and Mimiviridae: giant viruses with an increasing number of potential hosts, including corals and sponges. J Invertebr Pathol 2009;101:172–180.
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  34. Makarova KS, Wolf YI, Mekhedov SL, Mirkin BG, Koonin EV: Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res 2005;33:4626–4638.
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  39. Iyer LM, Koonin EV, Aravind L: Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal apses transcription factors. Genome Biol 2002;3:RESEARCH0012.
    External Resources
  40. Iyer LM, Makarova KS, Koonin EV, Aravind L: Comparative genomics of the FTSK-HERA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. Nucleic Acids Res 2004;32:5260–5279.
  41. Garcia AD, Aravind L, Koonin EV, Moss B: Bacterial-type DNA Holliday junction resolvases in eukaryotic viruses. Proc Natl Acad Sci USA 2000;97:8926–8931.