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Table of Contents
Vol. 28, No. 2, 2010
Issue release date: August 2010
Fetal Diagn Ther 2010;28:100–108

Contribution of Magnetic Resonance Imaging to Prenatal Differential Diagnosis of Renal Tumors: Report of Two Cases and Review of the Literature

Linam L.E. · Yu X. · Calvo-Garcia M.A. · Rubio E.I. · Crombleholme T.M. · Bove K. · Kline-Fath B.M.
Arkansas Children’s Hospital, Little Rock, Ark., USA

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Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms’ tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma. All can be diagnosed by ultrasound. Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities. We present one case each of Wilms’ tumor and mesoblastic nephroma, both detected on antenatal ultrasound and further studied with fetal magnetic resonance imaging.

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  1. Maymon R, Strauss S, Herman A, et al: The prenatal scan pitfall for the diagnosis of renal mass: case report. Prenat Diagn 2004;24:932–934.
  2. Chen WY, Lin CN, Chao CS, et al: Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging. Prenat Diagn 2003;23:927–931.
  3. Fuchs IB, Henrich W, Brauer M, et al: Prenatal diagnosis of congenital mesoblastic nephroma in two siblings. J Ultrasound Med 2003;22:823–827.
  4. Matsumura M, Nishi T, Sasaki Y, et al: Prenatal diagnosis and treatment strategy for congenital mesoblastic nephroma. J Pediatr Surg 1993;28:1607–1609.
  5. Blank E, Neerhout RC, Burry KA: Congenital mesoblastic nephroma and polyhydramnios. JAMA 1978;240:1504–1505.
  6. Liu YC, Mai YL, Chang CC, et al: The presence of hydrops fetalis in a fetus with congenital mesoblastic nephroma. Prenat Diagn 1996;16:363–365.
  7. Kim CH, Kim YH, Cho MK, et al: A case of fetal congenital mesoblastic nephroma with oligohydramnios. J Korean Med Sci 2007;22:357–361.
  8. Geller E, Smergel EM, Lowry PA: Renal neoplasms of childhood. Radiol Clin North Am 1997;35:1391–1413.
  9. Won HS, Jung E, Lee PR, et al: Prenatal detection of mesoblastic nephroma by sonography and magnetic resonance imaging. Ultrasound Obstet Gynecol 2002;19:197–199.
  10. Applegate KE, Ghei M, Perez-Atayde AR: Prenatal detection of a Wilms’ tumor. Pediatr Radiol 1999;29:65–67.
  11. Goldstein I, Shoshani G, Ben-Harus E, Sujov P: Prenatal diagnosis of congenital mesoblastic nephroma. Ultrasound Obstet Gynecol 2002;19:209–211.
  12. Kubik-Huch RA, Huisman TA, Wisser J, et al: Ultrafast MRI of the fetus. AJR Am J Roentgenol 2000;174:1599–1606.
  13. Irsutti M, Puget C, Baunin C, et al: Mesoblastic nephroma: prenatal ultrasonographic and MRI features. Pediatr Radiol 2000;30:147–150.
  14. Yamamoto N, Yoshizako T, Uchida N, et al: Mesoblastic nephroma: a case report of prenatal detection by MR imaging. Magn Reson Med Sci 2006;5:47–50.
  15. Vadeyar S, Ramsay M, James D, O’Neill D: Prenatal diagnosis of congenital Wilms’ tumor (nephroblastoma) presenting as fetal hydrops. Ultrasound Obstet Gynecol 2000;16:80–83.
  16. Ritchey ML, Azizkhan RG, Beckwith JB, et al: Neonatal Wilms’ tumor. J Pediatr Surg 1995;30:856–859.
  17. Nagahara A, Kawagoe M, Matsumoto F, et al: Botryoid Wilms’ tumor of the renal pelvis extending into the bladder. Urology 2006;67:845.
  18. Beckwith JB: Nephrogenic rests and the pathogenesis of Wilms’ tumor: developmental and clinical considerations. Am J Med Genet 1998;79:268–273.
  19. Beckwith JB, Kiviat NB, Bonadio JF: Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms’ tumor. Pediatr Pathol 1990;10:1–36.
  20. Bove KE, Koffler H, McAdams AJ: Nodular renal blastema. Definition and possible significance. Cancer 1969;24:323–332.
  21. Suresh I, Suresh S, Arumugam R, et al: Antenatal diagnosis of Wilms’ tumor. J Ultrasound Med 1997;16:69–72.

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