- Deep brain stimulation
- Speech intelligibility
- Parkinson’s disease
- Electric field
- Fasciculus cerebellothalamicus
Background/Aims: Deep brain stimulation (DBS) is widely used to treat motor symptoms in patients with advanced Parkinson’s disease. The aim of this study was to investigate the anatomical aspects of the electric field in relation to effects on speech and movement during DBS in the subthalamic nucleus. Methods: Patient-specific finite element models of DBS were developed for simulation of the electric field in 10 patients. In each patient, speech intelligibility and movement were assessed during 2 electrical settings, i.e. 4 V (high) and 2 V (low). The electric field was simulated for each electrical setting. Results: Movement was improved in all patients for both high and low electrical settings. In general, high-amplitude stimulation was more consistent in improving the motor scores than low-amplitude stimulation. In 6 cases, speech intelligibility was impaired during high-amplitude electrical settings. Stimulation of part of the fasciculus cerebellothalamicus from electrodes positioned medial and/or posterior to the center of the subthalamic nucleus was recognized as a possible cause of the stimulation-induced dysarthria. Conclusion: Special attention to stimulation-induced speech impairments should be taken in cases when active electrodes are positioned medial and/or posterior to the center of the subthalamic nucleus.
Copyright © 2010 S. Karger AG, Basel
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Mattias Åström, MSc
Department of Biomedical Engineering
SE–58185 Linköping (Sweden)
Tel. +46 736 290 978, E-Mail email@example.com
Conflict of Interest: Marwan Hariz and Ludvic Zrinzo occasionally received travel expenses from Medtronic to lecture at meetings.
Received: October 1, 2009
Accepted after revision: March 4, 2010
Published online: May 12, 2010
Number of Print Pages : 10
Number of Figures : 5, Number of Tables : 2, Number of References : 41
Stereotactic and Functional Neurosurgery
Vol. 88, No. 4, Year 2010 (Cover Date: July 2010)
Journal Editor: Roberts D.W. (Lebanon, N.H.)
ISSN: 1011-6125 (Print), eISSN: 1423-0372 (Online)
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