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Vol. 85, No. 2, 2010
Issue release date: September 2010

Association between Polymorphisms in the Serotonin 2C Receptor Gene and Premature Ejaculation in Han Chinese Subjects

Luo S. · Lu Y. · Wang F. · Xie Z. · Huang X. · Dong Q. · Zhang S.
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Introduction: Lifelong premature ejaculation (LPE) is characterized by persistently shorter intravaginal ejaculation latency time (IELT) than found acceptable by the patient or his partner. It has been postulated to be a neurobiological dysfunction with genetic vulnerability and is related to disturbances of central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and 5-HT receptor function. Aim: To investigate the relationship between the C–759T and G–697C polymorphisms of the 5-HT2C receptor and LPE. Methods: A prospective study was conducted in 106 Han Chinese men with LPE, characterized by IELT of less than 1 min, and 84 healthy controls with IELT of more than 3 min. All subjects were genotyped for the C–759T and G–697C polymorphisms located in the promoter region of the 5-HT2C receptor. The frequencies of genotypes and single nucleotide mutations were compared between the two groups. Results: Three genotypes were detected both in the men with LPE and in the control group: –759C/–697G, –759T/–697C, and –759C/ –697C. Genotype –759T/–697G was not detected. The frequency of genotype –759T/–697C was higher in patients with LPE than in the control group (30.2 vs. 11.9%, p < 0.05), whereas the frequency of genotype –759C/–697G was lower in patients with LPE than in the control group (66.0 vs. 83.3%, p < 0.05). No difference was found for genotype –759C/ –697C between the two groups. Mutations at –759T and –697C were more frequent in patients than in the control group (–759T: 30.2 vs. 13.3%, p < 0.05; –697C: 30.4 vs. 16.7%, p < 0.05, respectively). Conclusions: Our findings indicated that polymorphisms in the 5-HT2C receptor gene are associated with LPE, and men who carry the –759T or –697C genotype have increased odds of premature ejaculation. Further investigation in this field is necessary.

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  1. Goldstein I: Premature to early ejaculation: a sampling of manuscripts regarding the most common male sexual dysfunction published in IJIR: The Journal of sexual Medicine. Int J Impot Res 2003;15:307–308.
  2. Godpodinoff ML: Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther 1989;15:130–134.
  3. Waldinger MD: The neurobiological approach to premature ejaculation. J Urol 2002;168:2359–2367.
  4. Waldinger MD, Berendsen HH, Blok BF, Olivier B, Holstege G: Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 1998;92:111–118.
  5. Waldinger MD, Rietschel M, Nöthen MM, Hengeveld MW, Olivier B: Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998;8:37–40.
  6. Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier B: Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 2006;30:893–907.
  7. Jern P, Santtila P, Johansson A, Varjonen M, Witting K, Vonder Pahlen B, et al: Evidence for a genetic etiology to ejaculatory dysfunction. Int J Impot Res 2009;21:62–67.
  8. McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, et al: An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) Ad Hoc Committee for the definition of premature ejaculation. J Sex Med 2008;5:1590–1606.
  9. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM: Development and evaluation an abridged 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999;11:319–326.
  10. Paddy KC, Steven CB, Rethelyi J, Aeilko HZ, Daan JT, Olivier B, et al: Serotonin transporter promoter region (5-HTTLPR) polymorphisms is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med 2009;6:276–284.
  11. Yuan X, Yamada K, Ishiyama-Shigemoto S, Koyama W, Nonaka K: Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type 2 diabetes. Diabetologia 2000;43:373–376.
  12. Li J, Wang Y, Zhou R, Zhang H, Yang L, Wang B, et al: Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects. Neurosci Lett 2006;407:107–111.
  13. Schapiro B: Premature ejaculation: a review of 1130 cases. J Urol 1943;50:374–379.

    External Resources

  14. Waldinger MD, Rietschel M, Nöthen MM, Hengeveld MW, Olivier B: Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998;8:37–40.
  15. Abramowski D, Rigo M, Duc D: Localization of 5-hydroxytryptamine 2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 1995;34:1635–1645.
  16. Clemett DA, Punhani T, Duxon MS: Immunolohistochemical location of the 5-HT2C receptor protein in rat CNS. Neuropharmacology 2000;39:123–132.
  17. Klint T, Larsson K: Clozapine acts as a 5-HT2 antagonist by attenuating DOI induced inhibition of male rat sexual behavior. Psychopharmacology 1995;119:291–294.
  18. Mendelson SD, Gorzalka BB: Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine and 1-(m-chlorophenyl) piperazine on copulatory behavior in the rat. Neuropharmacology 1990;29:783–786.
  19. Pomerantz SM, Hepner BC, Wertz JM: 5-HT1A and 5-HT1C/AD receptor agonists produce reciprocal effects on male sexual behavior of rhesus monkeys. Eur J Pharmacol 1993;243:227–234.
  20. Barnes NM, Sharp T: A review of central 5-HT receptors and their function. Neuropharmacology 1999;38:1083–1152.
  21. Milatovich A, Hsieh CL, Bonaminio G, Tecott L, Julius D, Francke U: Serotonin receptor 1c gene assigned to X-chromosome in human (band q24) and mouse (bands D-F4). Hum Mol Genet 1992;1:681–684.
  22. Zhang Z, Zhang X, Yao Z, Chen J, Sun J, Yao H, et al: Association of antipsychotic agent-induced weight gain with a polymorphism of the promoter region of the 5-HT 2C receptor gene. Chin Med J 2002;82:1097–1101.
  23. Zhang ZJ, Zhang XB, Sha WW, Zhang XB, Reynolds GP: Association of a polymorphism in the receptor gene with tardive dyskinesia in patients with schizophrenia. Mol Psychiatry 2002;7:670–671.
  24. Ozbek E, Tasci AI, Tugcu V, Ilbey YO, Simsek A, Ozcan L, et al: Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population. Asian J Androl 2009;11:351–355.
  25. Safarinejad MR: Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran. J Urol 2009;181:2656–2661.

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