Journal Mobile Options
Table of Contents
Vol. 30, No. 1, 2010
Issue release date: August 2010
Dement Geriatr Cogn Disord 2010;30:39–42

Low Cancer Rates among Patients with Dementia in a Population-Based Register Study in Sweden

Attner B. · Lithman T. · Noreen D. · Olsson H.
Departments of aCancer Epidemiology and bOncology, Clinical Sciences, Lund University, Lund, Sweden

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in


Background: Some studies have suggested a lower incidence of cancer in patients with dementia. We studied this further for 18 cancer types in population-based registers. Methods: In 19,756 cases and in 147,324 age- and sex-matched controls a diagnosis of dementia was studied 9–45 months prior to the diagnosis of cancer. Results: Overall a diagnosis of dementia was significantly less common among the cancer cases (risk ratio, RR = 0.60; 95% CI = 0.52–0.69). Conclusion: The study confirms previous findings that patients with dementia have a lower risk of cancer. Because the effect was seen for all tumour types and especially for patients older than 70 years and since the deficit was more pronounced for patients with tumours situated within the body, the data suggest that malignancies are underdiagnosed for persons with dementia.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


  1. Roe CM, Behrens MI, Xiong C, Miller JP, Morris JC: Alzheimer disease and cancer. Neurology 2005;64:895–898.
  2. Roe CM, Fitzpatrick AL, Xiong C, Sieh W, Kuller L, Miller JP, et al: Cancer linked to Alzheimer disease but not vascular dementia. Neurology 2010;74:106–112.
  3. Prior P, Hassall C, Cross KW: Causes of death associated with psychiatric illness. J Public Health Med 1996;18:381–389.
  4. Bennett DA, Leurgans S: Is there a link between cancer and Alzheimer disease? Neurology 2010;74:100–101.
  5. Gupta SK, Lamont EB: Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia. J Am Geriatr Soc 2004;52:1681–1687.
  6. Drummond MF, Botten G, Hakkinen U, Pedersen KM: Assessing the quality of Swedish health economics research. Scand J Public Health 2006;34:566–567.
  7. Barlow L, Westergren K, Holmberg L, Talback M: The completeness of the Swedish Cancer Register: a sample survey for the year 1998. Acta Oncol 2009;48:27–33.
  8. National Board of Health and Welfare: Cancer Incidence in Sweden 2007. Health and Diseases 2008;11:1–117.
  9. Ganguli M, Dodge HH, Shen C, Pandav RS, DeKosky ST: Alzheimer disease and mortality: a 15-year epidemiological study. Arch Neurol 2005;62:779–784.
  10. Brunnstrom HR, Englund EM: Cause of death in patients with dementia disorders. Eur J Neurol 2009;16:488–492.
  11. Fu C, Chute DJ, Farag ES, Garakian J, Cummings JL, Vinters HV: Comorbidity in dementia: an autopsy study. Arch Pathol Lab Med 2004;128:32–38.
  12. Tremolizzo L, Rodriguez-Menendez V, Brighina L, Ferrarese C: Is the inverse association between Alzheimer’s disease and cancer the result of a different propensity to methylate DNA? Med Hypotheses 2006;66:1251–1252.
  13. Raji MA, Kuo YF, Freeman JL, Goodwin JS: Effect of a dementia diagnosis on survival of older patients after a diagnosis of breast, colon, or prostate cancer: implications for cancer care. Arch Intern Med 2008;168:2033–2040.
  14. Rozzini R, Trabucchi M: Patients with cancer who are affected by dementia do not die only because of cancer. Arch Intern Med 2009;169:633.
  15. Aevarsson O, Svanborg A, Skoog I: Seven-year survival rate after age 85 years: relation to Alzheimer disease and vascular dementia. Arch Neurol 1998;55:1226–1232.

Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00