Cover

Adipose Tissue Development

From Animal Models to Clinical Conditions
3rd ESPE Advanced Seminar in Developmental Endocrinology, Paris, March 2009

Editor(s): Levy-Marchal C. (Paris) 
Pénicaud L. (Dijon) 
Table of Contents
Vol. 19, No. , 2010
Section title: Paper
Levy-Marchal C, Pénicaud L (eds): Adipose Tissue Development: From Animal Models to Clinical Conditions. Endocr Dev. Basel, Karger, 2010, vol 19, pp 31–44
(DOI:10.1159/000316895)

Adipose Tissue and the Reproductive Axis: Biological Aspects

Hausman G.J. · Barb C.R.
USDA/ARS, Richard B. Russell Agriculture Research Center, Athens, Ga., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/15/2010
Cover Date: 2010

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9450-9 (Print)
eISBN: 978-3-8055-9451-6 (Online)

Abstract

The discovery of leptin has clearly demonstrated a relationship between body fat and the neuroendocrine axis since leptin influences appetite and the reproductive axis. Since adipose tissue is a primary source of leptin, adipose tissue is no longer considered as simply a depot to store fat. Recent findings demonstrate that numerous other genes, i.e. neuropeptides, interleukins and other cytokines and biologically active substances such as leptin and insulin-like growth factorsI and II, are also produced by adipose tissue, which could influence appetite and the reproductive axis. Targets of leptin in the hypothalamus include neuropeptide Y, proopiomelanocortin and kisspeptin. Transsynaptic connection of hypothalamic neurons to porcine adipose tissue may result in a direct influence of the hypothalamus on adipose tissue function. Nutritional signals such as leptin are detected by the central nervous system and translated by the neuroendocrine system into signals which ultimately regulates luteinizing hormone secretion. Furthermore, leptin directly affects gonadotropin-releasing hormone release from the hypothalamus, luteinizing hormone from the pituitary gland and ovarian follicular steroidogenesis. Although leptin is identified as a putative signal that links metabolic status and neuroendocrine control of reproduction, other adipocyte protein products may play key roles in regulating the reproductive axisin the pig.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/15/2010
Cover Date: 2010

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9450-9 (Print)
eISBN: 978-3-8055-9451-6 (Online)


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