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Vol. 3, No. 2, 2010
Issue release date: April – August
Section title: Published: July 2010
Open Access Gateway
Case Rep Oncol 2010;3:245–251
(DOI:10.1159/000318641)

Diabetic Mastopathy: A Case Report and Literature Review

Neetu G.a · Pathmanathan R.a · Weng N.K.b
aDepartment of Pathology, Monash University Sunway Campus, Bandar Sunway, Selangor, bDepartment of Surgery, Kuantan Specialist Hospital, Kuantan, Pahang, Malaysia
email Corresponding Author

Abstract

Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed.

© 2010 S. Karger AG, Basel


  

Key Words

  • Diabetic mastopathy
  • Insulin-dependent
  • Breast cancer
  • Pseudomalignancy

  

Author Contacts

G. Neetu
Department of Pathology, Monash University Sunway Campus, Bandar Sunway
Subang Jaya, Selangor 46150 (Malaysia)
Tel. +60 355 146 319, Fax +60 355 146 323E-Mail neetu.gopinath@med.monash.edu.my

  

Article Information

Published online: July 16, 2010
Number of Print Pages : 7

  

Publication Details

Case Reports in Oncology

Vol. 3, No. 2, Year 2010 (Cover Date: April - August)

Journal Editor: Markman M. (Houston, Tex.)
ISSN: NIL (Print), eISSN: 1662-6575 (Online)

For additional information: http://www.karger.com/CRO


Open Access License / Drug Dosage / Disclaimer

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Diabetic mastopathy is a rare fibroinflammatory breast disease characterized by lymphocytic lobulitis, ductitis, and perivasculitis with stromal fibrosis. This lesion often presents as a discretely palpable uni- or bilateral mass in long-standing type I diabetes and other autoimmune diseases. We report a case of insulin-dependent diabetic mastopathy, which presented clinically as an indeterminate breast lump suspicious for malignancy. The patient is a 36-year-old woman who had type 1 insulin-dependent diabetes mellitus. Mammography and ultrasonography raised a suspicion of malignancy, and an excisional biopsy was performed. A previous biopsy had shown no evidence of malignancy. Histopathological examination now showed dense keloid-like stromal fibrosis with epithelioid-like and spindly myofibroblasts and a characteristic lymphocytic infiltration around blood vessels in and around lobules and ducts, features consistent with diabetic mastopathy. The literature is briefly reviewed.

© 2010 S. Karger AG, Basel


  

Author Contacts

G. Neetu
Department of Pathology, Monash University Sunway Campus, Bandar Sunway
Subang Jaya, Selangor 46150 (Malaysia)
Tel. +60 355 146 319, Fax +60 355 146 323E-Mail neetu.gopinath@med.monash.edu.my

  

Article Information

Published online: July 16, 2010
Number of Print Pages : 7

  

Publication Details

Case Reports in Oncology

Vol. 3, No. 2, Year 2010 (Cover Date: April - August)

Journal Editor: Markman M. (Houston, Tex.)
ISSN: NIL (Print), eISSN: 1662-6575 (Online)

For additional information: http://www.karger.com/CRO


Article / Publication Details

First-Page Preview
Abstract of Published: July 2010

Published online: 7/16/2010
Issue release date: April – August

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: (Print)
eISSN: 1662-6575 (Online)

For additional information: http://www.karger.com/CRO


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.