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Table of Contents
Vol. 30, No. 1, 2010
Issue release date: August 2010
Section title: Original Research Article
Free Access
Dement Geriatr Cogn Disord 2010;30:83–92

Awareness of Memory Abilities in Community-Dwelling Older Adults with Suspected Dementia and Mild Cognitive Impairment

Lin F.a, e · Wharton W.b, d · Dowling N.M.c, d · Ries M.L.b, d · Johnson S.C.b, d, e · Carlsson C.M.b, d, e · Asthana S.b, d, e · Gleason C.E.b, d, e
aSchool of Nursing, bSection of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, and cDepartment of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, dWisconsin Alzheimer’s Disease Research Center and eGeriatric Research, Education and Clinical Center of the William S. Middleton Memorial Veteran’s Hospital, Madison, Wisc., USA
email Corresponding Author

Carey E. Gleason, PhD

Madison VA GRECC (D4211)

2500 Overlook Terrace

Madison, WI 53705 (USA)

Tel. +1 608 280 7000, Fax +1 608 280 7165, E-Mail ceg@medicine.wisc.edu


  1. Sternberg SA, Wolfson C, Baumgarten M: Undetected dementia in community-dwelling older people: the Canadian Study of Health and Aging. J Am Geriatr Soc 2000;48:1430–1434.
  2. Babinski J: Contribution to the study of mental disturbance in organic cerebral hemiplegia (anosognosia) (in French). Rev Neurol (Paris) 1914;12:845–848.
  3. Twamley EW, Ropacki SA, Bondi MW: Neuropsychological and neuroimaging changes in preclinical Alzheimer’s disease. J Int Neuropsychol Soc 2006;12:707–735.
  4. Tabert MH, Albert SM, Borukhova-Milov L, et al: Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology 2002;58:758–764.
  5. Kashiwa Y, Kitabayashi Y, Narumoto J, Nakamura K, Ueda H, Fukui K: Anosognosia in Alzheimer’s disease: association with patient characteristics, psychiatric symptoms and cognitive deficits. Psychiatry Clin Neurosci 2005;59:697–704.
  6. Starkstein SE, Jorge R, Mizrahi R, Robinson RG: A diagnostic formulation for anosognosia in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2006;77:719–725.
  7. Hannesdóttir K, Morris RG: Primary and secondary anosognosia for memory impairment in patients with Alzheimer’s disease. Cortex 2007;43:1020–1030.
  8. Gallo DA, Chen JM, Wiseman AL, Schacter DL, Budson AE: Retrieval monitoring and anosognosia in Alzheimer’s disease. Neuropsychology 2007;21:559–568.
  9. Agnew SK, Morris RG: The heterogeneity of anosognosia for memory impairment in Alzheimer’s disease: a review of the literature and a proposed model. Aging Ment Health 1998;2:7–19.
  10. Okonkwo OC, Griffith HR, Vance DE, Marson DC, Ball KK, Wadley VG: Awareness of functional difficulties in mild cognitive impairment: a multidomain assessment approach. J Am Geriatr Soc 2009;57:978–984.
  11. Vogel A, Stokholm J, Gade A, Andersen BB, Hejl AM, Waldemar G: Awareness of deficits in mild cognitive impairment and Alzheimer’s disease: do MCI patients have impaired insight? Dement Geriatr Cogn Disord 2004;17:181–187.
  12. Souchay C: Metamemory in Alzheimer’s disease. Cortex 2007;43:987–1003.
  13. Barrett AM, Eslinger PJ, Ballentine NH, Heilman KM: Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects. Neurology 2005;64:693–699.
  14. Sheikh JI, Yesavage JA: Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin Gerontol 1986;5:165–173.
    External Resources
  15. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4 (DSM-IV). Washington, American Psychiatric Association, 1994.
  16. Gauthier S, Reisberg B, Zaudig M, et al: Mild cognitive impairment. Lancet 2006;367:1262–1270.
  17. Reitan RM: Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 1958;8:271–276.
    External Resources
  18. Stroop JR: Studies of interference in serial verbal reactions. J Exp Psychol Gen 1935;18:643–662.
    External Resources
  19. Spreen O, Strauss E: A Compendium of Neuropsychological Tests. New York, Oxford University Press, 1998.
  20. Northern California Neurobehavioral Group: Manual for the Neurobehavioral Cognitive Status Examination. Fairfax, Northern California Neurobehavioral Group, 2001.
  21. Folstein MF, Folstein SE, McHugh PR: Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
  22. Sunderland T, Hill JL, Mellow AM, et al: Clock drawing in Alzheimer’s disease: a novel measure of dementia severity. J Am Geriatr Soc 1989;37:725–729.
  23. Morris JC, Edland S, Clark C, et al: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). 4. Rates of cognitive change in the longitudinal assessment of probable Alzheimer’s disease. Neurology 1993;43:2457–2465.
  24. Smith G, della Sala S, Logie RH, Maylor EA: Prospective and retrospective memory in normal ageing and dementia: a questionnaire study. Memory 2000;8:311–321.
  25. Welsh KA, Butters N, Mohs RC, et al: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). 5. A normative study of the neuropsychological battery. Neurology 1994;44:609–614.
  26. Mitrushina MN, Boone KB: Handbook of Normative Data for Neuropsychological Assessment. New York, Oxford University Press, 2005.
  27. Wagner MT, Spangenberg KB, Bachman DL, O’Connell P: Unawareness of cognitive deficit in Alzheimer disease and related dementias. Alzheimer Dis Assoc Disord 1997;11:125–131.
  28. SPSS 16.0 for Windows. Chicago, SPSS, 2007.
  29. Games PA, Howell JF: Pairwise multiple comparison procedures with unequal N’s and/or variances: a Monte Carlo study. J Educ Behav Stat 1976;1:113.
    External Resources
  30. MacKinnon JG, Davidson R: Estimation and Inference in Econometrics. New York, Oxford University Press, 1993.
  31. Hayes AF, Cai L: Using heteroskedasticity-consistent standard error estimators in OLS regression: an introduction and software implementation. Behav Res Methods 2007;39:709.
  32. Clement F, Belleville S, Gauthier S: Cognitive complaint in mild cognitive impairment and Alzheimer’s disease. J Int Neuropsychol Soc 2008;14:222–232.
  33. Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G: Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer’s disease. Int J Geriatr Psychiatry 2005;20:238–246.
  34. Kalbe E, Salmon E, Perani D, et al: Anosognosia in very mild Alzheimer’s disease but not in mild cognitive impairment. Dement Geriatr Cogn Disord 2005;19:349–356.
  35. Clare L: Awareness in early-stage Alzheimer’s disease: a review of methods and evidence. Br J Clin Psychol 2004;43:177–196.
  36. Ries ML, Jabbar BM, Schmitz TW, et al: Anosognosia in mild cognitive impairment: relationship to activation of cortical midline structures involved in self-appraisal. J Int Neuropsychol Soc 2007;13:450–461.
  37. Johnson SC, Ries ML, Hess TM, et al: Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults. Arch Gen Psychiatry 2007;64:1163–1171.
  38. Palmer K, Backman L, Winblad B, Fratiglioni L: Detection of Alzheimer’s disease and dementia in the preclinical phase: population-based cohort study. BMJ 2003;326:245.
  39. Roberts JL, Clare L, Woods RT: Subjective memory complaints and awareness of memory functioning in mild cognitive impairment: a systematic review. Dement Geriatr Cogn Disord 2009;28:95–109.
  40. Purser JL, Fillenbaum GG, Wallace RB: Memory complaint is not necessary for diagnosis of mild cognitive impairment and does not predict 10-year trajectories of functional disability, word recall, or short portable mental status questionnaire limitations. J Am Geriatr Soc 2006;54:335–338.
  41. Crowe M, Andel R, Wadley V, et al: Subjective cognitive function and decline among older adults with psychometrically defined amnestic MCI. Int J Geriatr Psychiatry 2006;21:1187–1192.