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Vol. 88, No. 6, 2010
Issue release date: November 2010
Stereotact Funct Neurosurg 2010;88:367–373

Predicting Acute Affective Symptoms after Deep Brain Stimulation Surgery in Parkinson’s Disease

Schneider F. · Reske M. · Finkelmeyer A. · Wojtecki L. · Timmermann L. · Brosig T. · Backes V. · Amir-Manavi A. · Sturm V. · Habel U. · Schnitzler A.
aDepartment of Psychiatry and Psychotherapy, RWTH Aachen University, and bJARA, Translational Brain Medicine, Aachen, cDepartment of Neurology and dInstitute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, and eDepartment of Neurology, University Hospital Cologne, and fDepartment of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany; gDepartment of Psychiatry, University of California San Diego, San Diego, Calif., USA

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The current study aimed to investigate predictive markers for acute symptoms of depression and mania following deep brain stimulation (DBS) surgery of the subthalamic nucleus for the treatment of motor symptoms in Parkinson’s disease (PD). Fourteen patients with PD (7 males) were included in a prospective longitudinal study. Neuropsychological tests, psychopathology scales and tests of motor functions were administered at several time points prior to and after neurosurgery. Pre-existing psychopathological and motor symptoms predicted postoperative affective side effects of DBS surgery. As these can easily be assessed, they should be considered along with other selection criteria for DBS surgery.

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