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Vol. 62, No. 3, 2010
Issue release date: August 2010
Section title: Original Paper
Neuropsychobiology 2010;62:182–192
(DOI:10.1159/000319360)

Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women

Gizewski E.R. · Rosenberger C. · de Greiff A. · Moll A. · Senf W. · Wanke I. · Forsting M. · Herpertz S.
Departments of aDiagnostic and Interventional Radiology and Neuroradiology and bPsychosomatic Medicine and Psychotherapy, University Hospital Essen, Essen, and cClinic of Psychosomatic Medicine and Psychotherapy, LWL-University Clinic Bochum, Ruhr-University Bochum, Bochum, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/13/2009
Accepted: 12/6/2009
Published online: 7/22/2010

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Background: There is evidence that patients with anorexia nervosa (AN) demonstrate specific cerebral activation patterns in response to visual food stimulation. We postulated that cerebral activation patterns could represent different perceptions of high-calorie images during hunger and satiety and could be determined by patients’ subjective ratings. Methods: After 6 h of starvation and also in a state of satiety, 12 female patients with AN and 12 normal-weight women were assessed by use of fMRI with high-calorie food images. All patients suffered from a restrictive type of AN. Heart rates, subjective ratings of satiety and valences of the visual stimuli were assessed. Results: Food stimuli presented during a state of hunger were associated with significant activation of the anterior cingulate cortex and insula in the control group and of the prefrontal and central cortices and insula in the AN group. During the hunger state activation in AN of the dorsal posterior cingulate cortex was revealed compared to the controls. In the state of satiety, activation of the left insula was observed in the AN group. Use of the food valence judgment as a covariate confirmed the insula activation and revealed additional activation of the orbitofrontal, cingulate and medial temporal cortices. Conclusion: Our results indicate differences in cerebral activation patterns due to different perceptions of high-calorie food images, modulated by feelings of hunger or satiety, among AN patients with modulation by subjective ratings of food valence.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/13/2009
Accepted: 12/6/2009
Published online: 7/22/2010

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

  1. Wittchen HU, Nelson CB, Lachner G: Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychol Med 1998;28:109–126.
  2. Milos G, Spindler A, Schnyder U, Martz J, Hoek HW, Willi J: Incidence of severe anorexia nervosa in Switzerland: 40 years of development. Int J Eat Disord 2004;35:250–258.
  3. Hoek HW, van Hoeken D: Review of the prevalence and incidence of eating disorders. Int J Eat Disord 2003;34:383–396.
  4. Bulik CM, Sullivan PF, Fear JL, Pickering A: Outcome of anorexia nervosa: eating attitudes, personality, and parental bonding. Int J Eat Disord 2000;28:139–147.
  5. Zipfel S, Lowe B, Reas DL, Deter HC, Herzog W: Long-term prognosis in anorexia nervosa: lessons from a 21-year follow-up study. Lancet 2000;355:721–722.
  6. Halmi KA, Eckert E, Marchi P, Sampugnaro V, Apple R, Cohen J: Comorbidity of psychiatric diagnoses in anorexia nervosa. Arch Gen Psychiatry 1991;48:712–718.
  7. Garner DM: Pathogenesis of anorexia nervosa. Lancet 1993;341:1631–1635.
  8. Bulik CM, Sullivan PF, Wade TD, Kendler KS: Twin studies of eating disorders: a review. Int J Eat Disord 2000;27:1–20.
  9. Kendler KS: Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 2001;58:1005–1014.
  10. Kaye WH, Klump KL, Frank GK, Strober M: Anorexia and bulimia nervosa. Annu Rev Med 2000;51:299–313.
  11. Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Mathis CA, Wagner A, Thornton L, Hoge J, Ziolko SK, Becker CR, McConaha CW, Kaye WH: Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa. Biol Psychiatry 2007;61:1090–1099.
  12. Frank GK, Bailer UF, Henry S, Wagner A, Kaye WH: Neuroimaging studies in eating disorders. CNS Spectr 2004;9:539–548.
  13. Ellison Z, Foong J, Howard R, Bullmore E, Williams S, Treasure J: Functional anatomy of calorie fear in anorexia nervosa. Lancet 1998;352:1192.
  14. Gordon CM, Dougherty DD, Fischman AJ, Emans SJ, Grace E, Lamm R, Alpert NM, Majzoub JA, Rauch SL: Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography. J Pediatr 2001;139:51–57.
  15. Nozoe S, Naruo T, Nakabeppu Y, Soejima Y, Nakajo M, Tanaka H: Changes in regional cerebral blood flow in patients with anorexia nervosa detected through single photon emission tomography imaging. Biol Psychiatry 1993;34:578–580.
  16. Naruo T, Nakabeppu Y, Sagiyama K, Munemoto T, Homan N, Deguchi D, Nakajo M, Nozoe S: Characteristic regional cerebral blood flow patterns in anorexia nervosa patients with binge/purge behavior. Am J Psychiatry 2000;157:1520–1522.
  17. Seeger G, Braus DF, Ruf M, Goldberger U, Schmidt MH: Body image distortion reveals amygdala activation in patients with anorexia nervosa – a functional magnetic resonance imaging study. Neurosci Lett 2002;326:25–28.
  18. Shirao N, Okamoto Y, Okada G, Yamawaki S: Temporomesial activation in young females associated with unpleasant words concerning body image. Neuropsychobiology 2003;48:136–142.
  19. Wagner A, Ruf M, Braus DF, Schmidt MH: Neuronal activity changes and body image distortion in anorexia nervosa. Neuroreport 2003;14:2193–2197.
  20. Uher R, Murphy T, Friederich HC, Dalgleish T, Brammer MJ, Giampietro V, Phillips ML, Andrew CM, Ng VW, Williams SC, Campbell IC, Treasure J: Functional neuroanatomy of body shape perception in healthy and eating-disordered women. Biol Psychiatry 2005;58:990–997.
  21. Santel S, Baving L, Krauel K, Munte TF, Rotte M: Hunger and satiety in anorexia nervosa: fMRI during cognitive processing of food pictures. Brain Res 2006;1114:138–148.
  22. Muhlau M, Gaser C, Ilg R, Conrad B, Leibl C, Cebulla MH, Backmund H, Gerlinghoff M, Lommer P, Schnebel A, Wohlschlager AM, Zimmer C, Nunnemann S: Gray matter decrease of the anterior cingulate cortex in anorexia nervosa. Am J Psychiatry 2007;164:1850–1857.
  23. LaBar KS, Gitelman DR, Parrish TB, Kim YH, Nobre AC, Mesulam MM: Hunger selectively modulates corticolimbic activation to food stimuli in humans. Behav Neurosci 2001;115:493–500.
  24. Gordon CM, Dougherty DD, Rauch SL, Emans SJ, Grace E, Lamm R, Alpert NM, Majzoub JA, Fischman AJ: Neuroanatomy of human appetitive function: a positron emission tomography investigation. Int J Eat Disord 2000;27:163–171.
  25. Gautier JF, Chen K, Salbe AD, Bandy D, Pratley RE, Heiman M, Ravussin E, Reiman EM, Tataranni PA: Differential brain responses to satiation in obese and lean men. Diabetes 2000;49:838–846.
  26. Phan KL, Wager T, Taylor SF, Liberzon I: Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 2002;16:331–348.
  27. Simon D, Craig KD, Miltner WH, Rainville P: Brain responses to dynamic facial expressions of pain. Pain 2006;126:309–318.
  28. Herpertz S, Moll A, Gizewski E, Tagay S, Senf W: Distortion of hunger and satiation in patients with restrictive anorexia nervosa. Psychother Psychosom Med Psychol 2008;58:409–415.
  29. Uher R, Brammer MJ, Murphy T, Campbell IC, Ng VW, Williams SC, Treasure J: Recovery and chronicity in anorexia nervosa: brain activity associated with differential outcomes. Biol Psychiatry 2003;54:934–942.
  30. Uher R, Murphy T, Brammer MJ, Dalgleish T, Phillips ML, Ng VW, Andrew CM, Williams SC, Campbell IC, Treasure J: Medial prefrontal cortex activity associated with symptom provocation in eating disorders. Am J Psychiatry 2004;161:1238–1246.
  31. Vogt BA: Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 2005;6:533–544.
  32. Margulies DS, Kelly AM, Uddin LQ, Biswal BB, Castellanos FX, Milham MP: Mapping the functional connectivity of anterior cingulate cortex. Neuroimage 2007;37:579–588.
  33. Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M: Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 2001;124:1720–1733.
  34. Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O’Brien CP: Limbic activation during cue-induced cocaine craving. Am J Psychiatry 1999;156:11–18.
  35. Garavan H, Pankiewicz J, Bloom A, Cho JK, Sperry L, Ross TJ, Salmeron BJ, Risinger R, Kelley D, Stein EA: Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am J Psychiatry 2000;157:1789–1798.
  36. Maas LC, Lukas SE, Kaufman MJ, Weiss RD, Daniels SL, Rogers VW, Kukes TJ, Renshaw PF: Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. Am J Psychiatry 1998;155:124–126.
  37. Stark R, Zimmermann M, Kagerer S, Schienle A, Walter B, Weygandt M, Vaitl D: Hemodynamic brain correlates of disgust and fear ratings. Neuroimage 2007;37:663–673.
  38. Fuster JM: Frontal lobes. Curr Opin Neurobiol 1993;3:160–165.
  39. Rowe JB, Eckstein D, Braver T, Owen AM: How does reward expectation influence cognition in the human brain? J Cogn Neurosci 2008;20:1980–1992.
  40. Matochik JA, London ED, Yildiz BO, Ozata M, Caglayan S, DePaoli AM, Wong ML, Licinio J: Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J Clin Endocrinol Metab 2005;90:2851–2854.
  41. Golden NH, Ashtari M, Kohn MR, Patel M, Jacobson MS, Fletcher A, Shenker IR: Reversibility of cerebral ventricular enlargement in anorexia nervosa, demonstrated by quantitative magnetic resonance imaging. J Pediatr 1996;128:296–301.
  42. Wittchen HU, Zaudig M, Fydrich T: Strukturiertes Klinisches Interview für DSM-IV (SKID-I). Göttingen, Hogrefe, 1997.
  43. Fichter MM, Herpertz S, Quadflieg N, Herpertz-Dahlmann B: Structured Interview for anorexic and bulimic disorders for DSM-IV and ICD-10: updated (third) revision. Int J Eat Disord 1998;24:227–249.
  44. Friston KJ, Holmes AP, Poline JB, Grasby PJ, Williams SC, Frackowiak RS, Turner R: Analysis of fMRI time-series revisited. Neuroimage 1995;2:45–53.
  45. Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ: Multisubject fMRI studies and conjunction analyses. Neuroimage 1999;10:385–396.
  46. Friston KJ, Frith CD, Frackowiak RS, Turner R: Characterizing dynamic brain responses with fMRI: a multivariate approach. Neuroimage 1995;2:166–172.