Free Access
Dement Geriatr Cogn Disord 2010;30:121–130
(DOI:10.1159/000319537)

An MRI-Based Semiquantitative Index for the Evaluation of Brain Atrophy and Lesions in Alzheimer’s Disease, Mild Cognitive Impairment and Normal Aging

Chen W.a, g · Song X.a, b · Zhang Y.g · Darvesh S.c, e · Zhang N.a, g · D’Arcy R.C.N.a, d · Black S.f · Rockwood K.b, e
aNational Research Council Canada, Institute for Biodiagnostics (Atlantic), bDivision of Geriatric Medicine, Department of Medicine, cDepartments of Medicine (Neurology) and Anatomy and Neurobiology, and dDepartments of Radiology and Psychology and Neuroscience, Dalhousie University, and eCentre for Health Care of the Elderly, QEII Health Sciences Centre, Halifax, N.S., and fDepartment of Medicine (Neurology) and Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont., Canada; gDepartment of Radiology of the General Hospital, Tianjin Medical University, Tianjin, China
email Corresponding Author


 goto top of outline Key Words

  • Aging
  • Alzheimer’s disease
  • Brain lesions
  • Brain atrophy
  • Mild cognitive impairment

 goto top of outline Abstract

Background: This study investigates how T1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer’s disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T1- and T2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

Copyright © 2010 S. Karger AG, Basel


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 goto top of outline Author Contacts

Xiaowei Song, PhD, MSCS; Kenneth Rockwood, MD, FRCPC
Neuroimaging Research Laboratory, National Research Council Canada
Institute for Biodiagnostics (Atlantic)
Suite 3900, 1796 Summer Street, Halifax, NS B3H 3A7 (Canada)
E-Mail Xiaowei.Song@nrc.ca; Kenneth.Rockwood@dal.ca


 goto top of outline Article Information

Data used in the preparation of this article were partly obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (www.loni.ucla.edu/ADNI). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in the analysis or writing of this report. The principal investigator of the initiative is Dr. Michael W. Weiner. A complete list of the ADNI investigators can be found at the following website: www.loni.ucla.edu/ADNI/Collaboration/ADNI_Manuscript_Citations.pdf.

Accepted: July 6, 2010
Published online: August 21, 2010
Number of Print Pages : 10
Number of Figures : 5, Number of Tables : 4, Number of References : 31


 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 30, No. 2, Year 2010 (Cover Date: September 2010)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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