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Cerebrovasc Dis 2010;30:362–373
(DOI:10.1159/000319564)

Longitudinal Trajectories of Cognitive Decline among Older Adults with Cardiovascular Disease

Okonkwo O.C.a · Cohen R.A.b · Gunstad J.d · Tremont G.b, c · Alosco M.L.c · Poppas A.b
aDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Md., bDepartment of Psychiatry and Human Behavior, Brown Medical School, and cNeuropsychology Program, Rhode Island Hospital, Providence, R.I., and dDepartment of Psychology, Kent State University, Kent, Ohio, USA
email Corresponding Author


 Outline


 goto top of outline Key Words

  • Cardiovascular disease
  • Vascular cognitive impairment
  • Cognitive decline

 goto top of outline Abstract

Background: The long-term course of cognitive impairments secondary to cardiovascular disease (CVD) is unclear. In this study, we prospectively investigated the temporal pattern, rate and hierarchy of cognitive decline attributable to CVD – a risk factor for the development of vascular cognitive impairment (VCI) – and examined the influence of cardiac surgery and heart failure on cognitive decline. Methods: A total of 172 older adults with CVD were administered a comprehensive battery of neuropsychological tests at study entry, and at 12 and 36 months thereafter. Random coefficient regressions were used to investigate the temporal course, rate and hierarchy of cognitive decline, as well as to examine the effect of heart failure (reported by 21% of the sample) and cardiac surgery (reported by 44% of the sample) on trajectories of cognitive change. Results: The course of decline in cognition was linear for language and attention-executive function-psychomotor speed, and curvilinear for visuospatial abilities, memory and overall cognition. The decline in attention-executive function-psychomotor speed was smaller than the decline in other domains. The greatest decline occurred in visuospatial abilities. The rate of decline in cognition was not altered by a history of heart failure. Patients who had undergone cardiac surgery exhibited slower deceleration in their rates of decline in overall cognition. At baseline, patients with a history of heart failure had comparatively poorer attention-executive function-psychomotor speed, overall cognition and, to a lesser extent, visuospatial scores. Conclusion: There is measurable decline in neurocognitive function among patients with CVD. This decline is linear in some cognitive domains and curvilinear in others and is not attributable to the normal aging process. Cardiac surgery, but not heart failure, significantly affects the trajectory of cognitive decline. Because most vascular risk factors are modifiable, preventive measures such as lifestyle changes may be useful in retarding cognitive decline among patients with CVD, thus preventing the onset of VCI.

Copyright © 2010 S. Karger AG, Basel


goto top of outline Introduction

There has been a renewed interest in understanding the nature and extent of cognitive impairment secondary to vascular disease [1] as a result of the growing recognition that persons with cardiovascular disease (CVD) experience diminution in cognitive function even in the absence of major cardiac events or clinically relevant stroke [2]. CVD-associated cognitive impairments often impact everyday functional abilities [3,4,5], even when the impairments are not so severe as to incur a diagnosis of dementia [6,7]. Indeed, an emerging consensus in the field proposes that cognitive impairment attributable to vascular disorders should be viewed along a continuum, ranging from minimal cognitive difficulties (i.e. ‘brain at risk’) to frank dementia [1,8,9].

While CVD-associated cognitive impairments vary as a function of the underlying etiology [9,10], deficits in attention, executive functions, psychomotor speed and information processing are most common [10,11,12,13]. Impairment in these cognitive domains is presumed to be due to disruption of frontal and subcortical brain systems [14], with support for this position coming from studies that have demonstrated relationships between white matter lesions on neuroimaging and select cognitive deficits among persons with vascular diseases [15,16]. It is also well established that specific vascular factors (e.g. body mass index, serum cholesterol concentration and systolic blood pressure [17,18]) as well as some indices of vascular integrity (e.g. systemic perfusion, brachial artery reactivity and carotid intima-media thickness [19,20,21,22,23]) or metabolic function (e.g. C-reactive protein and brain natriuretic peptide [24,25,26]) are associated with cognitive performance in persons with CVD.

A question that has not received sufficient attention relates to the long-term course of cognitive impairments attributable to CVD. For example, whereas it is established that CVD is associated with select deficits in the attention-executive function-psychomotor speed domain, it remains unknown whether performance in this domain deteriorates more precipitously compared to other cognitive domains. Furthermore, we currently do not know whether cognitive decline in this population proceeds linearly (similar to the progressive decline observed in Alzheimer’s disease), or whether some nonlinear trajectory obtains. Prior studies that have examined cognitive decline due to CVD have either used data from two time points (e.g. baseline and a follow-up period) [24,27,28,29] or were restricted to patients who underwent coronary artery bypass graft (CABG) [30,31,32]. Therefore, their ability to provide information regarding the rate, hierarchy and temporal course of CVD-related cognitive decline, or regarding cognitive decline in the general population of patients with CVD, was limited.

In this study, we attempted to address these crucial knowledge gaps by investigating cognitive function over a 3-year period in a cohort of ambulatory older adults with a variety of CVD, and by representing a wide range of cognitive functioning. Our primary aims were to determine (i) the temporal pattern of cognitive change, and (ii) whether cognitive change occurred comparably across all domains. Given that chronic CVD has shown to be linked to the development of vascular cognitive impairment (VCI) [6], and because cognitive decline in VCI likely does not occur in the same inexorably progressive manner as is seen in Alzheimer’s disease, we expected to find a curvilinear course of cognitive change in this cohort. We expected to observed declines in the domain of attention-executive function-psychomotor speed though hypothesized that significant declines would also be evident across other domains, reflecting the impact of chronic CVD on global cognitive function. As secondary aims, we separately examined the effects of two cardiac factors – heart failure and CABG/heart valve surgery – on cognitive change in this cohort. We hypothesized that patients who had a history of these factors would exhibit a comparatively faster rate of decline in cognitive function.

 

goto top of outline Patients and Methods

goto top of outline Participants

The sample consisted of 172 community-dwelling individuals enrolled in a prospective study examining cognitive function among older adults with CVD. They were recruited from local hospitals, cardiac rehabilitation programs, cardiology practices, and by advertisement. To be enrolled in the study, participants had to be between 55 and 85 years old and have an established history of CVD including myocardial infarction, cardiac surgery, heart failure, atrial fibrillation and hypertension. Exclusion criteria included end-stage heart disease, history of traumatic brain injury with loss of consciousness exceeding 10 min, neurological diseases (e.g. Parkinson’s disease), current depressed mood, major psychiatric illness (e.g. bipolar disorder and schizophrenia) and MRI contraindications (e.g. pacemaker implant). Persons with Alzheimer’s disease and other dementias (including vascular dementia) were also excluded. Of note, persons with a history of clinically manifest stroke were excluded from this study. Written informed consent was obtained from all participants as part of this study approved by the institutional review board. Table 1 details the characteristics of the participants at baseline. Of the 172 participants who completed the baseline evaluation, 106 subsequently had a 12-month follow-up evaluation, and 100 subsequently had a 36-month follow-up evaluation.

TAB01
Table 1. Characteristics of participants at baseline

goto top of outline Neuropsychological Assessment

A comprehensive neuropsychological test battery was administered to all participants at each study visit. All tests were administered and scored by trained technicians, using standardized procedures and under the supervision of a licensed clinical neuropsychologist (R.A.C.). In addition to screening measures of global cognition (i.e. Mini-Mental State Examination, MMSE, and Dementia Rating Scale, 2nd edition, DRS-2), the neurocognitive battery assessed the domains of language, visuospatial abilities, memory and attention-executive function-psychomotor speed, using psychometric instruments with established reliabilities and validities [33]. Table 2 presents the specific tests used as well as the participants’ test scores at baseline. Of note, as in our prior studies, the attention-executive function-psychomotor speed domain consisted of measures presumably mediated by frontal-subcortical systems [19,21,24,25,26,29].

TAB02
Table 2. Neuropsychological test performance at baseline

goto top of outline Brain MRI Protocol and White Matter Hyperintensity Quantification

A small subset of the participants (n = 39) underwent brain MRI using a Siemens Symphony 1.5-tesla unit. This subgroup consisted of 14 women and 25 men with a mean age (± SD) of 71.44 (± 7.24) years, mean education of 13.92 (± 2.16) years, mean MMSE score of 28.92 (± 1.11), mean DRS-2 total score of 137.90 (± 4.64), and a Beck Depression Inventory II score of 4.32 (± 2.90). They differed significantly from those participants who did not undergo MRI regarding age (71.44 vs. 68.66 years; p = 0.039), MMSE (28.92 vs. 28.35; p = 0.017), systolic blood pressure SD (11.18 vs. 7.17 mm Hg; p < 0.001) and history of diabetes (10.3 vs. 25.2%; p = 0.047), but not regarding any other baseline characteristic.

The imaging protocol included axial T1-, T2- and FLAIR (fluid-attenuated inversion recovery)-weighted images (field of view = 24.7; matrix = 192 × 256; TR/TE = 6,000/105; 5-mm-thick slices/ 2-mm gap). The FLAIR images were imported into Analyze 5.0® (Biomedical Imaging Resource; Mayo Foundation, Rochester, Minn., USA), where the skull was stripped and the brain stem and cerebellum removed, leaving only brain parenchyma. Next, utilizing a semiautomated threshold method in Analyze, the total number of voxels representing white matter hyperintensities (WMH) were isolated from each slice and summed to calculate the participant’s total WMH. Of note, each slice was visually reviewed by 2 trained raters and edited as needed. These raters achieved intra- and interrater reliabilities of >0.90. Total WMH volume was normalized to total brain volume by using the formula: (total WMH volume/total brain volume) × 100. This normalization yielded an index of total WMH load relative to the total amount of brain tissue and reflected the degree of total brain volume impacted by WMH.

goto top of outline Data Analyses

Participants’ scores on the measures that constituted each neurocognitive domain were Z-transformed (using sample means and SD at respective time points), summed and averaged to create a composite variable representing that domain at that time point. To ensure that higher scores on all the composites indicated better performance, Z scores for neuropsychological tests whose unit of measurement is completion time (e.g. trails A) were multiplied by –1 prior to the creation of the composite measures to correct for the fact that shorter completion time reflects better performance. In addition, a fifth composite measure, ‘overall cognition’, was created by summing and averaging participants’ scores on each neurocognitive composite (i.e. language, visuospatial abilities, memory and attention-executive function-psychomotor speed). A similar procedure has been used in prior studies [4,30].

To investigate the temporal course of change in cognitive function, we fitted random coefficient regressions that modeled participants’ scores on each cognitive composite across the 3 time points under consideration [34]. Random coefficient regression, also called individual growth curve modeling, provides a flexible approach to analyzing longitudinal data. It easily accommodates variability in the number and spacing of assessment points across study participants [30,34]. In addition, because it assumes that each individual’s observed scores are a random sample of data from their underlying true growth curve, it facilitates analyses that include all participants, even those with only one wave of data [34]. Of particular interest to our study, it allows an examination of temporal patterns in the data.

To determine whether cognitive change in our sample proceeded linearly or curvilinearly, we fitted 2 sets of models for each cognitive domain. In one set, we only tested a linear term for time (i.e. year), whereas in the other set, we included linear (i.e. year) and quadratic (i.e. year × year) terms for time. The year effect from the linear models would reveal the annual rate of change in cognitive function, whereas the year × year effect from the quadratic model would indicate the rate of acceleration or deceleration in cognitive change over time. Additionally, for both linear and quadratic models, we first tested a model that only adjusted for baseline performance on the cognitive domain being examined and then tested another model that adjusted for baseline performance and age. Given that the linear models are nested within the quadratic models, in addition to examining the p value of the year × year terms so as to determine whether a quadratic model fit the data, we also performed deviance tests (i.e. –2LL linear model minus –2LL quadratic model) to ascertain the incremental fit of each quadratic model relative to its corresponding, more parsimonious linear model. Because all neurocognitive composites are on the same metric (i.e. Z scores), the magnitude and sign of their regression estimates would indicate whether change occurred comparably across all neurocognitive domains.

The polynomial specification for time (i.e. linear or quadratic) that emerged as optimal for each cognitive domain was subsequently employed in further random coefficient regressions that examined the effects of 2 cardiac factors – major cardiac surgery (i.e. CABG or heart valve surgery) and heart failure – on change in cognition. In these latter models, we fitted terms for (i) age, baseline performance on the cognitive domain, cardiac factor, year and cardiac factor × year when the optimal polynomial specification for time was linear, or (ii) age, baseline performance, cardiac factor, year, year × year, cardiac factor × year and cardiac factor × year × year when the optimal polynomial specification for time was quadratic. For these models, the primary term of interest was the highest-order group-by-time interaction (i.e. cardiac factor × year for the linear models and cardiac factor × year × year for the quadratic models) because it would indicate whether those with a history of the cardiac factor – say, heart failure – have a significantly different change trajectory compared to those without such a history. Specifically, for the linear models, cardiac factor × year would reveal the estimated difference in annual rate of change in cognition between patients with and without a history of the factor under study, whereas for the quadratic models, cardiac factor × year × year would reveal the estimated difference in rate of acceleration or deceleration in cognitive change between patients with and without a history of the cardiac factor under investigation.

All analyses were performed using SPSS 16.0 (SPSS Inc., Chicago, Ill., USA). Only findings with a two-tailed p ≤ 0.05 were considered significant.

 

goto top of outline Results

goto top of outline Analysis of Attrition

The72 patients who failed to complete the 36-month evaluation withdrew for various reasons, the most common being a worsening of their CVD (which affected their ability to participate actively in the study) and death. Analyses of baseline scores between those who completed the study and those who withdrew revealed that the withdrawers had significantly poorer language, visuospatial, overall cognition and MMSE scores compared to the completers. The withdrawers also tended to perform poorer on memory. In addition, they had significantly less years of education, and significantly higher baseline serum C-reactive protein. No other group differences emerged in the variables examined. These results are presented in table 3.

TAB03
Table 3. Group differences at baseline: patients who completed the study versus those who withdrew

goto top of outline Temporal Pattern and Rate of Change in Cognitive Function

The random coefficient regressions revealed both linear and curvilinear patterns of change in cognitive function (fig. 1). The models that examined change in cognition as a function of linear time revealed that, as a group, the study participants experienced significant declines in all cognitive domains and on overall cognition. These declines ranged from 0.02 to 0.05 of an SD per year. When the analyses were repeated while adjusting for age (in addition to the original adjustment for baseline performance on the cognitive domain), results remained virtually unchanged. On the other hand, the models that treated time as a quadratic function revealed significant decelerations in the rate of cognitive decline for visuospatial abilities, memory and overall cognition, which ranged from 0.03 to 0.06 of an SD. After additional adjustment for age, these decelerations persisted. These results are presented in table 4. Deviance tests, using –2LL values from the baseline- and age-adjusted models, were conducted to ascertain that quadratic time truly provided better fit to the visuospatial, memory and overall cognition data, relative to the more parsimonious linear time. These tests confirmed the superiority of the quadratic time effect: visuospatial abilities [χ2(1) = 5.90; p = 0.015], memory [χ2(1) = 5.17; p = 0.023] and overall cognition [χ2(1) = 11.45; p < 0.001].

TAB04
Table 4. Growth curve models of temporal course and rate of change in cognitive function

FIG01
Fig. 1. Temporal patterns of change in cognitive function across time. The regression lines for language and attention-executive function-psychomotor speed were derived from linear models, whereas those for visuospatial abilities, memory and overall cognition were derived from quadratic models.

goto top of outline Hierarchy of Change across Cognitive Domains

Examination of the estimates from the linear time random coefficient regressions reported above revealed that the rate of decline in the attention-executive functions-psychomotor speed domain was lower than the decline in other cognitive domains. The greatest decline was observed in the visuospatial domain (barring rounding) (table 4). However, as can be appreciated from the 95% confident limits reported in table 4, there was considerable overlap in the CI of the domains’ slopes, making it difficult to assert that any domain declined significantly faster or slower than others did.

goto top of outline Change in Cognition as a Function of Cardiac Factors

Based on the deviance tests reported above, quadratic time was deemed optimal for visuospatial abilities, memory and overall cognition, whereas linear time appeared more fitting for the other domains. Table 5 details the results of the random coefficient regressions that examined the effect of major cardiac surgery (which was reported by 44% of the sample) on change trajectory. The only significant difference in the trajectories of those with a history of cardiac surgery relative to those without such a history occurred on overall cognition. Whereas those without a history of cardiac surgery experienced a deceleration of 0.05 in the rate of decline in overall cognition (not shown in table 5), those who had undergone cardiac surgery experienced a deceleration of 0.01 (i.e. 0.05–0.04). This finding is illustrated in figure 2. Because these random coefficient regressions adjusted for baseline performance in respective cognitive domains, they did not permit an assessment of the effect of cardiac surgery on cognitive performance at baseline. Therefore, we performed an exploratory multivariate analysis of variance, adjusting for age, to examine whether there were any differences at baseline between patients with and without a history of cardiac surgery. This analysis failed to find any multivariate (or univariate) difference between these 2 patient groups at baseline: λ = 0.96, F(4, 166) = 1.76, p = 0.139.

TAB05
Table 5. Effect of cardiac factors on trajectories of change in cognition

FIG02
Fig. 2. Effect of major cardiac surgery on change in overall cognition.

Table 5 also details the results of the analyses that examined the effect of heart failure (reported by 21% of the sample) on change trajectory. There were no differences in the trajectories of those with a history of heart failure compared to those without such a history. We then performed an exploratory multivariate analysis of variance, adjusting for age, to examine the effect of heart failure on cognitive performance at baseline. This analysis revealed a significant multivariate difference between patients with and without a history of heart failure: λ = 0.92, F(4, 130) = 3.03, p = 0.020. An examination of univariate effects revealed that patients with a history of heart failure had significantly lower baseline scores on attention-executive functions-psychomotor speed (estimate: –0.38; SE: 0.11; p < 0.001) and overall cognition (estimate: –0.24; SE: 0.11; p = 0.027) relative to those without such a history. They also tended to have lower baseline visuospatial scores (estimate: –0.27; SE: 0.16; p = 0.087).

goto top of outline Exploratory Examination of Change in Cognition as a Function of Total WMH

To determine whether total WMH load had any impact on cognitive decline, we performed exploratory random effect analyses that regressed longitudinal scores on each cognitive domain (1) on age, baseline performance on the cognitive domain, year, total WMH and total WMH × year (for those domains wherein linear time was optimal), or (2) on age, baseline performance, year, total WMH, year × year, total WMH × year and total WMH × year × year (for those domains wherein quadratic time was optimal). These analyses revealed that total WMH was not a significant predictor of decline on any cognitive domain within the subset (n = 39) of subjects who had imaging data (language: total WMH × year = –0.01, SE = 0.03, p = 0.887; attention-executive functions-psychomotor speed: total WMH × year = 0.02, SE = 0.02, p = 0.340; visuospatial abilities: total WMH × year × year = 0.06, SE = 0.04, p = 0.178; memory: total WMH × year × year = –0.02, SE = 0.03, p = 0.536; overall cognition: total WMH × year × year = 0.01, SE = 0.02, p = 0.609).

 

goto top of outline Discussion

Although there is increased recognition that older adults with vascular risk factors or diseases experience cognitive impairments even in the absence of stroke or other major cardiac events [1,2,17,18,21], there has not been a systemic attempt to prospectively investigate the cognitive outcome of these persons. Accordingly, in this study, we examined change in cognition among a cohort of older adults with a wide range of CVD as well as attendant cognitive dysfunction. To our knowledge, this study represents the first attempt to address this important issue.

Our primary aims were to characterize the temporal course of CVD-associated change in cognitive function and to determine whether cognitive change occurred at the same rate across all domains. Our results demonstrated that cognitive change occurred in a linear fashion in some domains (language and attention-executive functions-psychomotor speed) and curvilinearly in others (visuospatial abilities, memory and overall cognition). Although it is not entirely clear why decline was linear in some cognitive domains and curvilinear in other domains, a plausible hypothesis is that the curvilinear trajectories represent a gradual recovery of cognitive functioning as a result of intensive treatment. If that is the case, then a longer follow-up of this cohort (in the context of ongoing treatment) might also reveal curvilinearity in the currently linear trajectories for language and attention-executive functions-psychomotor speed.

Inspection of the parameter estimates from the models that specified a linear function of time indicated that decline in attention-executive-psychomotor functions occurred slower than decline in other cognitive domains. This finding is somewhat counterintuitive, given that past cross-sectional research indicates that various vascular abnormalities (e.g. reduced ejection fraction and cardiac output, impaired brachial artery reactivity, carotid artery thickening and elevated C-reactive protein) impair attention-executive functions-psychomotor speed but not other cognitive functions [19,20,21,22,23,24]. Even so, there is equal evidence that patients with chronic CVD show impairments in other cognitive domains besides attention-executive functions-psychomotor speed [6,35,36,37]. Indeed, the term ‘dementia’ in vascular dementia presupposes impairments in multiple cognitive domains. Accordingly, our current finding of comparatively higher rates of decline in language, visuospatial abilities and memory suggests that while vascular integrity may be most strongly associated with attention-executive functions-psychomotor speed at any given point in time, the cumulative effect of CVD over time results in more generalized cognitive impairment. It is important to note that the cognitive decline observed in this cohort is not simply attributable to the patients’ aging as the decrements persisted even after adjusting for age in the models. In addition, the significant curvilinear change trajectories provide further support for the view that observed declines are not likely proxies for aging, given that age proceeds linearly.

A handful of studies have previously examined change in cognition as a result of vascular alterations [24,27,28]. Hoth et al. [24] reported that, over a 1-year period, CVD patients demonstrated worsening of constructional praxis, but improvements in visual scanning and immediate verbal recall. Another study that was also conducted over a 1-year span [27] found that patients with VCI exhibited improvements in verbal learning and recall, and decrements in processing speed. In the Canadian Study of Health and Aging [28], there was evidence of a significant decline in global cognition among persons classified as having ‘VCI – no dementia’ at both study entry and 5 years later, indicating that deterioration in cognition occurs even in the absence of progression to a severer diagnostic status (i.e. dementia). As noted earlier, these studies are somewhat limited by the use of only two time points. Nonetheless, their findings are important for providing initial information regarding the evolution of CVD-related cognitive dysfunction.

Given current interest in the potential contributions of reduced cardiac output [19,21,38,39,40,41] and major cardiac surgery [31,32,42,43,44] to cognitive decline among patients with CVD, we examined the association between history of heart failure or CABG/heart valve surgery and cognitive decline over the duration of the study. Our analyses failed to find a significant association between heart failure and rate of decline on any of the cognitive domains tested. Even so, we found that patients with heart failure had comparatively lower baseline scores on the attention-executive functions-psychomotor speed, overall cognition and, to a lesser extent, visuospatial domains. The apparent preservation of cognitive function over time among patients with heart failure might be due to the fact that many of them were receiving intense treatment including placement of ventricular stimulators, which shored up their cognition. Our findings are consonant overall with results from prior studies that investigated differences in cognitive performance between persons with and without a history of heart failure [40,41,45,46]. Possible mechanisms for cognitive dysfunction in heart failure include systemic hypoperfusion [19,20,40,45,47], cerebral hypoperfusion [39], cardiogenic emboli [41,48], cerebral infarcts [39], biochemical alterations (e.g. in serum concentrations of renin, aldosterone, sodium and potassium) [49,50] and endothelial abnormalities [21,51,52].

The sole association between history of major cardiac surgery and rate of decline in cognition emerged in overall cognition, wherein patients who had undergone cardiac surgery showed a slower rebound in performance compared to CVD patients who had not undergone surgery. This finding suggests that cardiac surgery in this cohort had some effect on change in cognitive function beyond that due to the vascular disease itself. The literature on the effects of cardiac surgery on cognition is mixed. Whereas some studies report that cardiac surgery impairs cognition [31,32], others have found inconsistent [42] or no evidence of such impairment [30,53]. The reasons for this variability are not entirely clear. Although surgery-related cognitive dysfunction is often believed to be iatrogenic, this presumption has not been borne out by empirical studies [31,53]. Similarly, postoperative cognitive impairments have been shown to be unrelated perioperative strokes [44]. The lack of unequivocal associations between cardiac surgery and postoperative cognitive dysfunction may be consistent with the idea that cognitive decline following cardiac surgery is not due to surgery per se or surgery-related complications, but rather due to a progression of the underlying vascular diseases [30]. Clearly, further studies are warranted to better understand the dynamics of the association between cardiac surgery and prospective cognitive function.

Over the past decade, the relationship between cerebrovascular disease (typically quantified as amount of WMH on MRI scans) and cognitive impairment has received great attention [7,15,54,55], and several groups, including ours, have reported that WMH load is associated with cognitive decline [16,56,57]. However, in the subset of participants who had MRI data in this study, we failed to find any associations between total WMH and rate of cognitive decline. It is possible that our negative findings are primarily due to our small sample size. Our findings may also suggest that in this subsample, cognitive decline was primarily a result of other factors associated with chronic CVD (e.g. the effects of chronic and general cerebral hypoperfusion) and of related complications rather than solely of white matter damage attributable to microvascular disease.

It is worth noting that patients who failed to complete the entire 36 months of the study had poorer baseline cognitive performance, less education and, for the most part, greater cardiovascular burden, particularly as indexed by serum C-reactive protein levels. It is theoretically plausible that patients who are more impaired at baseline would experience greater declines over time compared to those who are more intact. Accordingly, the worsening of cognitive performance over time that was observed in this study may actually underestimate the actual cognitive change that occurred in the original sample as a whole. The finding that withdrawers had comparatively worse cognitive functioning at baseline also underscores a potentially important clinical consideration when monitoring functional outcome among patients with CVD. Patients who show the greatest vulnerability to functional decline may be the most likely to be lost to follow-up such that their health care providers are unaware of their deteriorating functional status. It might be beneficial to direct particular effort toward developing effective ways of keeping these patients involved in ongoing health care.

A potential limitation of this study stems from the fact that the cohort consisted of a heterogeneous sample of older adults with CVD of varying severity. This issue primarily impacts the interpretation of the effects of specific cardiovascular factors such as heart failure or cardiac surgery. The parent study was not designed to examine the influence of a specific cardiovascular etiological factor such as cardiac surgery. Rather, its goal was to investigate how specific vascular physiological alterations such as reduced cardiac output, blood pressure variability and arterial stiffening influence cognitive outcome. In this regard, heterogeneity was necessary if the study’s aims were to be feasibly tested. On the other hand, this heterogeneity has the benefit of making our sample more representative of the population of older adults with CVD, thus making it more likely that our findings will be generalized to other clinical settings. Another limitation is that most of these patients were receiving treatment for their vascular diseases. The extent to which our findings are affected by this fact is uncertain. The relative ethnic homogeneity of this cohort (primarily Caucasian) may also represent a limitation insofar as our findings may not replicate within a more ethnically diverse cohort. Finally, we only tested a specific nonlinear function of time. It is possible that a different curvilinear function of time (e.g. logarithmic) would have fit the data just as well, potentially leading to alternative conclusions regarding the temporal course of cognitive change in this cohort.

Despite these limitations, this study is unique in its prospective examination of the rate, hierarchy and temporal pattern of cognitive change among older adults with a variety of CVD – and exhibiting a range of baseline cognitive functioning from fairly intact to marked deficits – using an extensive neurocognitive battery. Therefore, it stands to make important contributions to the growing literature on vascular-related cognitive dysfunction. Future studies from our group will examine the demographic, systemic, vascular and neuroimaging predictors of change in cognition in this heterogeneous cohort of ambulatory older adults with CVD.

 

goto top of outline Acknowledgment

This research was supported by grant R01 AG017975 from the National Institute on Aging, USA.


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 goto top of outline Author Contacts

Ozioma C. Okonkwo
Department of Neurology, Johns Hopkins University School of Medicine
1620 McElderry Street, Reed Hall East 2
Baltimore, MD 21205 (USA)
Tel. +1 410 502 2188, Fax +1 410 502 2189, E-Mail ozioma@jhmi.edu


 goto top of outline Article Information

Received: August 6, 2009
Accepted: April 15, 2010
Published online: August 5, 2010
Number of Print Pages : 12
Number of Figures : 2, Number of Tables : 5, Number of References : 57


 goto top of outline Publication Details

Cerebrovascular Diseases

Vol. 30, No. 4, Year 2010 (Cover Date: September 2010)

Journal Editor: Hennerici M.G. (Mannheim)
ISSN: 1015-9770 (Print), eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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