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Significant Association between IL-17F Promoter Region Polymorphism and Susceptibility to Asthma in a Korean Population

Jin E.-H.a · Choi E.-Y.a · Yang J.Y.a · Chung H.-T.c · Yang Y.-S.a, b
aGenome Research Center for Immune Disorders and bDepartment of Ophthalmology, School of Medicine, Wonkwang University, Iksan, and cSchool of Biological Sciences, University of Ulsan, Ulsan, Korea Int Arch Allergy Immunol 2011;155:106–110 (DOI:10.1159/000319804)

Abstract

Background: Individual differences in susceptibility to asthma would be expected because of common DNA variants of single nucleotide polymorphisms (SNPs) across populations. The pro-inflammatory cytokine IL-17F has homology with the IL-17 motif and induces the expression of other inflammatory cytokines in airway epithelial cells. This study aimed to identify IL-17F gene polymorphisms and to determine a possible association between these polymorphisms and susceptibility to asthma through a case-control study in a Korean population. Methods: We identified SNPs in the IL-17F gene by sequencing. Genotyping was conducted using the high-resolution melting (HRM) method on 424 asthma patients and 548 healthy controls. Results: The genotype and allele frequencies of rs1889570 SNP were significantly different between asthma patients and healthy controls (p = 0.001 and 0.002, respectively). The rs1889570 SNP genotype was also positively associated with the number of peripheral blood eosinophils in asthma patients (p = 0.03). The frequencies of haplotypes AA (p = 0.01), GG (p = 0.01) and AG (p = 0.006) were significantly different between asthma patients and healthy controls. Conclusions: In this study, we confirmed that the rs1889570 polymorphism of the IL-17F gene is associated with susceptibility to asthma in a Korean population.

 

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