Body Composition and Aging

Editor(s): Mobbs C.V. (New York, N.Y.) 
Hof P.R. (New York, N.Y.) 
Table of Contents
Vol. 37, No. , 2010
Section title: Paper
Mobbs CV, Hof PR (eds): Body Composition and Aging. Interdiscipl Top Gerontol. Basel, Karger, 2010, vol 37, pp 157–174

Exercise as a Calorie Restriction Mimetic: Implications for Improving Healthy Aging and Longevity

Huffman D.M.
Department of Medicine and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, N.Y., USA

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Calorie restriction (CR) is the only paradigm that has consistently increased lifespan in a wide variety of model organisms. Many hypotheses have been proposed as the underlying mechanism, including a reduction in body size and adiposity, which is commonly observed in calorie-restricted animals. This has led to investigations as to whether similar changes in body composition produced by increasing energy expenditure via exercise can replace or enhance the benefits of reducing energy intake. The goal of this chapter is to review and discuss the evidence regarding exercise as a CR mimetic for healthy aging and longevity. In rodents, the data clearly show that exercise, regardless of body weight changes, can improve health and survival, but unlike CR, fails to extend lifespan. In humans, short-term weight loss studies show that exercise and CR produce similar improvements in disease risk factors and biomarkers of aging, while some parameters clearly benefit more with exercise. Epidemiologic evidence in humans supports exercise as a strategy to reduce the risk of morbidity and mortality, but not to extend lifespan. It is unknown whether CR can extend human lifespan, but the metabolic profile of humans engaged in long-term CR shares many similarities with calorie restricted rodents and nonhuman primates. In conclusion, like CR, exercise can limit weight gain and adiposity, but only CR can extend lifespan. Therefore, in rodents, the ability of CR to slow aging is apparently more dependent on decreasing nutrient flux, rather than changes in energy balance and body composition.

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  1. Weindruch R, Walford R: The Retardation of Aging and Disease by Dietary Restriction. New York, Thomas, 1988;
  2. Tannenbaum A: The dependence of the genesis of induced skin tumors on the caloric intake during different stages of carcinogenesis. Cancer Res 1944;4:673-679
  3. Kealy RD, Lawler DF, Ballam JM, Mantz SL, Biery DN, Greeley EH, Lust G, Segre M, Smith GK, Stowe HD: Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc 2002;220:1315-1320
  4. Roth GS, Ingram DK, Lane MA: Caloric restriction in primates and relevance to humans. Ann NY Acad Sci 2001;928:305-315
  5. Pinney DO, Stephens DF, Pope LS: Lifetime effects of winter supplemental feed level and age at first parturition on range beef cows. J Anim Sci 1972;34:1067-1074
  6. Pugh TD, Klopp RG, Weindruch R: Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging 1999;20:157-165
  7. Masoro EJ: Caloric restriction-induced life extension of rats and mice: a critique of proposed mechanisms. Biochim Biophys Acta 2009;1790:1040-1048
  8. Barzilai N, Gupta G: Revisiting the role of fat mass in the life extension induced by caloric restriction. J Gerontol A Biol Sci Med Sci 1999;54:B89-B96discussion B97–B98
  9. Michell AR: Longevity of British breeds of dog and its relationships with sex, size, cardiovascular variables and disease. Vet Rec 1999;145:625-629
  10. Bartke A: Insulin and aging. Cell Cycle 2008;7:3338-3343
  11. Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N: Visceral adipose tissue modulates mammalian longevity. Aging Cell 2008;7:438-440
  12. Walker SP, Rimm EB, Ascherio A, Kawachi I, Stampfer MJ, Willett WC: Body size and fat distribution as predictors of stroke among US men. Am J Epidemiol 1996;144:1143-1150
  13. Pischon T, et al: General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008;359:2105-2120
  14. Holloszy JO, Smith EK: Effects of exercise on longevity of rats. Fed Proc 1987;46:1850-1853
  15. Holloszy JO: Mortality rate and longevity of food-restricted exercising male rats: a reevaluation. J Appl Physiol 1997;82:399-403
  16. Holloszy JO, Smith EK, Vining M, Adams S: Effect of voluntary exercise on longevity of rats. J Appl Physiol 1985;59:826-831
  17. Holloszy JO, Schechtman KB: Interaction between exercise and food restriction: effects on longevity of male rats. J Appl Physiol 1991;70:1529-1535
  18. Samorajski T, Delaney C, Durham L, Ordy JM, Johnson JA, Dunlap WP: Effect of exercise on longevity, body weight, locomotor performance, and passive-avoidance memory of C57BL/6J mice. Neurobiol Aging 1985;6:17-24
  19. Holloszy JO: Exercise increases average longevity of female rats despite increased food intake and no growth retardation. J Gerontol 1993;48:B97-B100
  20. Pekkanen J, Marti B, Nissinen A, Tuomilehto J, Punsar S, Karvonen MJ: Reduction of premature mortality by high physical activity: a 20-year follow-up of middle-aged Finnish men. Lancet 1987;i:1473-1477
  21. Postorino M, Marino C, Tripepi G, Zoccali C: Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol 2009;53:1265-1272
  22. Price GM, Uauy R, Breeze E, Bulpitt CJ, Fletcher AE: Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. Am J Clin Nutr 2006;84:449-460
  23. Gollisch KS, Brandauer J, Jessen N, Toyoda T, Nayer A, Hirshman MF, Goodyear LJ: Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats. Am J Physiol Endocrinol Metab 2009;297:E495-E504
  24. Holloszy JO: Longevity of exercising male rats: effect of an antioxidant supplemented diet. Mech Ageing Dev 1998;100:211-219
  25. Fontana L, Klein S, Holloszy JO: Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) 2010;32:97-108
  26. Slentz CA, Holloszy JO: Body composition of physically inactive and active 25-month-old female rats. Mech Age Dev 1993;69:161-166
  27. Huffman DM, Moellering DR, Grizzle WE, Stockard CR, Johnson MS, Nagy TR: Effect of exercise and calorie restriction on biomarkers of aging in mice. Am J Physiol Regul Integr Comp Physiol 2008;294:R1618-R1627
  28. Fontana L, Klein S, Holloszy JO: Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Am J Clin Nutr 2006;84:1456-1462
  29. Ji LL: Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 1999;222:283-292
  30. Chung HY, Kim HJ, Kim JW, Yu BP: The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann NY Acad Sci 2001;928:327-335
  31. Jay O, Reardon FD, Webb P, Ducharme MB, Ramsay T, Nettlefold L, Kenny GP: Estimating changes in mean body temperature for humans during exercise using core and skin temperatures is inaccurate even with a correction factor. J Appl Physiol 2007;103:443-451
  32. Goto S, Naito H, Kaneko T, Chung HY, Radak Z: Hormetic effects of regular exercise in aging: correlation with oxidative stress. Appl Physiol Nutr Metab 2007;32:948-953
  33. Ji LL, Gomez-Cabrera MC, Vina J: Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann NY Acad Sci 2006;1067:425-435
  34. Ji LL: Exercise-induced modulation of antioxidant defense. Ann NY Acad Sci 2002;959:82-92
  35. Morton JP, MacLaren DP, Cable NT, Bongers T, Griffiths RD, Campbell IT, Evans L, Kayani A, McArdle A, Drust B: Time course and differential responses of the major heat shock protein families in human skeletal muscle following acute nondam-aging treadmill exercise. J Appl Physiol 2006;101:176-182
  36. Radak Z, Chung HY, Goto S: Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology 2005;6:71-75
  37. Radak Z, Chung HY, Koltai E, Taylor AW, Goto S: Exercise, oxidative stress and hormesis. Ageing Res Rev 2008;7:34-42
  38. Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Bluher M: Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 2009;106:8665-8670
  39. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeu-wenburgh C: Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009;8:18-30
  40. Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H: The cytokine response to strenuous exercise. Can J Physiol Pharmacol 1998;76:505-511
  41. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Good-paster BH, Kritchevsky SB, Pahor M: Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 2008;56:2045-2052
  42. Silverman NE, Nicklas BJ, Ryan AS: Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women. Calcif Tissue Int 2009;84:257-265
  43. Petersen AM, Pedersen BK: The role of IL-6 in mediating the anti-inflammatory effects of exercise. J Physiol Pharmacol 2006;57:(suppl 10)43-51
  44. Vieira VJ, Valentine RJ, Wilund KR, Antao N, Bay-nard T, Woods JA: Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am J Physiol Endo-crinol Metab 2009;296:E1164-E1171
  45. Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E: Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006;295:1539-1548
  46. Mattison JA, Lane MA, Roth GS, Ingram DK: Calorie restriction in rhesus monkeys. Exp Gerontol 2003;38:35-46
  47. Lane MA, Baer DJ, Rumpler WV, Weindruch R, Ingram DK, Tilmont EM, Cutler RG, Roth GS: Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci USA 1996;93:4159-4164
  48. Magwere T, Pamplona R, Miwa S, Martinez-Diaz P, Portero-Otin M, Brand MD, Partridge L: Flight activity, mortality rates, and lipoxidative damage in Drosophila. J Gerontol A Biol Sci Med Sci 2006;61:136-145
  49. Barja G: Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Biol Med 2002;33:1167-1172
  50. Fontana L, Klein S, Holloszy JO, Premachandra BN: Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. J Clin Endocrinol Metab 2006;91:3232-3235
  51. Rikke BA, Yerg JE, 3rd, Battaglia ME, Nagy TR, Allison DB, Johnson TE: Strain variation in the response of body temperature to dietary restriction. Mech Ageing Dev 2003;124:663-678
  52. Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C, Dechaud H, Rinaldi S, Zeleniuch-Jacquotte A, Shore RE, Riboli E: Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst 2000;92:1592-1600
  53. Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B: Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 2009;8:277-287
  54. Kappeler L, De Magalhaes Filho C, Dupont J, Leneuve P, Cervera P, Perin L, Loudes C, Blaise A, Klein R, Epelbaum J, Le Bouc Y, Holzenberger M: Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol 2008;6:e254
  55. Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P: Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci USA 2008;105:3438-3442
  56. Fontana L, Meyer TE, Klein S, Holloszy JO: Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk. Rejuvenation Res 2007;10:225-234
  57. Reaven EP, Reaven GM: Structure and function changes in the endocrine pancreas of aging rats with reference to the modulating effects of exercise and caloric restriction. J Clin Invest 1981;68:75-84
  58. Reaven GM, Reaven EP: Prevention of age-related hypertriglyceridemia by caloric restriction and exercise training in the rat. Metabolism 1981;30:982-986
  59. Craig BW, Garthwaite SM, Holloszy JO: Adipocyte insulin resistance: effects of aging, obesity, exercise, and food restriction. J Appl Physiol 1987;62:95-100
  60. Mattson MP: Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res 2000;886:47-53
  61. Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP: Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2007;26:212-220
  62. Stranahan AM, Lee K, Becker KG, Zhang Y, Maud-sley S, Martin B, Cutler RG, Mattson MP: Hippo-campal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging 2008;Epub ahead of print
  63. Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, Mattson MP: Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus 2009;19:951-961
  64. Dellwo M, Beauchene RE: The effect of exercise, diet restriction, and aging on the pituitary–adrenal axis in the rat. Exp Gerontol 1990;25:553-562
  65. Levenson CW, Rich NJ: Eat less, live longer? New insights into the role of caloric restriction in the brain. Nutr Rev 2007;65:412-415
  66. Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO: Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005;310:314-317
  67. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H: Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev 1994;76:215-224
  68. Cui L, Hofer T, Rani A, Leeuwenburgh C, Foster TC: Comparison of lifelong and late life exercise on oxidative stress in the cerebellum. Neurobiol Aging 2009;30:903-909
  69. Kim JH, Kwak HB, Leeuwenburgh C, Lawler JM: Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat. Exp Gerontol 2008;43:317-329
  70. Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C: Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6. J Gerontol A Biol Sci Med Sci 2006;61:211-217
  71. Erdos B, Broxson CS, Landa T, Scarpace PJ, Leeu-wenburgh C, Zhang Y, Tumer N: Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus. Exp Geron-tol 2007;42:745-752
  72. Seo AY, Hofer T, Sung B, Judge S, Chung HY, Leeuwenburgh C: Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxid Redox Signal 2006;8:529-538
  73. Wohlgemuth SE, Seo AY, Marzetti E, Lees HA, Leeuwenburgh C: Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol 2010;45:138-148
  74. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO: Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized controlled trial. Am J Physiol Endocrinol Metab 2007;293:E197-E202
  75. Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C: Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res 2008;11:793-799
  76. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO: Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr 2006;84:1033-1042
  77. Weiss EP, Villareal DT, Racette SB, Steger-May K, Premachandra BN, Klein S, Fontana L: Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuvenation Res 2008;11:605-609
  78. Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E: Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 2007;4:e76
  79. Larson-Meyer DE, Redman L, Heilbronn LK, Martin CK, Ravussin E: Caloric restriction with or without exercise: the fitness versus fatness debate. Med Sci Sports Exerc 2010;42:152-159
  80. Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, Greenway FL, Williamson DA, Smith SR, Ravussin E: Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis 2009;203:206-213
  81. Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO: Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med 2006;166:2502-2510
  82. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO: Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J Appl Physiol 2007;102:634-640
  83. Laughlin MH: Cardiovascular response to exercise. Am J Physiol 1999;277:S244-S259
  84. Wendel-Vos GC, Schuit AJ, Feskens EJ, Boshuizen HC, Verschuren WM, Saris WH, Kromhout D: Physical activity and stroke. A meta-analysis of observational data. Int J Epidemiol 2004;33:787-798
  85. Laaksonen DE, et al: Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes 2005;54:158-165
  86. Vainionpaa A, Korpelainen R, Leppaluoto J, Jamsa T: Effects of high-impact exercise on bone mineral density: a randomized controlled trial in premeno-pausal women. Osteoporos Int 2005;16:191-197
  87. Roth SM, Ferrell RF, Hurley BF: Strength training for the prevention and treatment of sarcopenia. J Nutr Health Aging 2000;4:143-155
  88. Friedenreich CM: Physical activity and breast cancer risk: the effect of menopausal status. Exerc Sport Sci Rev 2004;32:180-184
  89. Slattery ML, Edwards S, Curtin K, Ma K, Edwards R, Holubkov R, Schaffer D: Physical activity and colorectal cancer. Am J Epidemiol 2003;158:214-224
  90. Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE: Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med 2004;351:2694-2703
  91. Wright CE, Zborowski JV, Talbott EO, McHugh-Pemu K, Youk A: Dietary intake, physical activity, and obesity in women with polycystic ovary syndrome. Int J Obes Relat Metab Disord 2004;28:1026-1032
  92. Hannan LM, Leitzmann MF, Lacey JV, Jr, Colbert LH, Albanes D, Schatzkin A, Schairer C: Physical activity and risk of ovarian cancer: a prospective cohort study in the United States. Cancer Epidemiol Biomarkers Prev 2004;13:765-770
  93. Alfano CM, Klesges RC, Murray DM, Bowen DJ, McTiernan A, Vander Weg MW, Robinson LA, Cartmel B, Thornquist MD, Barnett M, Goodman GE, Omenn GS: Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers. Cancer Epidemiol Biomarkers Prev 2004;13:2233-2241
  94. Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, Greenop KR, Almeida OP: Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008;300:1027-1037
  95. Rolland Y, Pillard F, Klapouszczak A, Reynish E, Thomas D, Andrieu S, Riviere D, Vellas B: Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am Geriatr Soc 2007;55:158-165
  96. Morris JN, Heady JA, Raffle PA, Roberts CG, Parks JW: Coronary heart-disease and physical activity of work. Lancet 1953;265:1111-1120
  97. Lee IM, Hsieh CC, Paffenbarger RS, Jr: Exercise intensity and longevity in men: The Harvard Alumni Health Study. JAMA 1995;273:1179-1184
  98. Sherman SE, D’Agostino RB, Cobb JL, Kannel WB: Physical activity and mortality in women in the Framingham Heart Study. Am Heart J 1994;128:879-884
  99. Stessman J, Hammerman-Rozenberg R, Cohen A, Ein-Mor E, Jacobs JM: Physical activity, function, and longevity among the very old. Arch Intern Med 2009;169:1476-1483
  100. Yates LB, Djousse L, Kurth T, Buring JE, Gaziano JM: Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. Arch Intern Med 2008;168:284-290
  101. Lee IM, Paffenbarger RS, Jr: Associations of light, moderate, and vigorous intensity physical activity with longevity: The Harvard Alumni Health Study. Am J Epidemiol 2000;151:293-299
  102. Slattery ML, Jacobs DR, Jr, Nichaman MZ: Leisure time physical activity and coronary heart disease death: the US Railroad Study. Circulation 1989;79:304-311
  103. Teramoto M, Bungum TJ: Mortality and longevity of elite athletes. J Sci Med Sport 2009;
  104. Schnohr P, Parner J, Lange P: Joggers live longer: The Osterbro study. Ugeskr Laeger 2001;163:2633-2635
  105. Vestergaard S, Patel KV, Bandinelli S, Ferrucci L, Guralnik JM: Characteristics of 400-meter walk test performance and subsequent mortality in older adults. Rejuvenation Res 2009;12:177-184
  106. Manini TM, Everhart JE, Patel KV, Schoeller DA, Colbert LH, Visser M, Tylavsky F, Bauer DC, Goodpaster BH, Harris TB: Daily activity energy expenditure and mortality among older adults. JAMA 2006;296:171-179
  107. Paffenbarger RS, Jr, Lee IM: Intensity of physical activity related to incidence of hypertension and all-cause mortality: an epidemiological view. Blood Press Monit 1997;2:115-123
  108. Finley CE, LaMonte MJ, Waslien CI, Barlow CE, Blair SN, Nichaman MZ: Cardiorespiratory fitness, macronutrient intake, and the metabolic syndrome: the Aerobics Center Longitudinal Study. J Am Diet Assoc 2006;106:673-679
  109. Lee CD, Blair SN, Jackson AS: Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr 1999;69:373-380
  110. Lee S, Kuk JL, Katzmarzyk PT, Blair SN, Church TS, Ross R: Cardiorespiratory fitness attenuates metabolic risk independent of abdominal subcutaneous and visceral fat in men. Diabetes Care 2005;28:895-901
  111. Blair SN, Kampert JB, Kohl HW, 3rd, Barlow CE, Macera CA, Paffenbarger RS, Jr, Gibbons LW: Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 1996;276:205-210
  112. Barlow CE, LaMonte MJ, Fitzgerald SJ, Kampert JB, Perrin JL, Blair SN: Cardiorespiratory fitness is an independent predictor of hypertension incidence among initially normotensive healthy women. Am J Epidemiol 2006;163:142-150
  113. Blair SN, Kohl HW, 3rd, Paffenbarger RS, Jr, Clark DG, Cooper KH, Gibbons LW: Physical fitness and all-cause mortality: a prospective study of healthy men and women. JAMA 1989;262:2395-2401
  114. Stevens J, Cai J, Evenson KR, Thomas R: Fitness and fatness as predictors of mortality from all causes and from cardiovascular disease in men and women in the lipid research clinics study. Am J Epidemiol 2002;156:832-841
  115. McAuley P, Pittsley J, Myers J, Abella J, Froelicher VF: Fitness and fatness as mortality predictors in healthy older men: the veterans exercise testing study. J Gerontol A Biol Sci Med Sci 2009;64:695-699
  116. Speakman JR, Hambly C: Starving for life: what animal studies can and cannot tell us about the use of caloric restriction to prolong human lifespan. J Nutr 2007;137:1078-1086
  117. Gaesser GA: Exercise for prevention and treatment of cardiovascular disease, type 2 diabetes, and metabolic syndrome. Curr Diab Rep 2007;7:14-19
  118. Ingram DK, Roth GS, Lane MA, Ottinger MA, Zou S, de Cabo R, Mattison JA: The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology 2006;7:143-148
  119. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R: Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009;325:201-204
  120. Fontana L, Meyer TE, Klein S, Holloszy JO: Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk. Rejuvenation Res 2007;10:225-234
  121. Willcox DC, Willcox BJ, Todoriki H, Curb JD, Suzuki M: Caloric restriction and human longevity: what can we learn from the Okinawans?. Biogeron-tology 2006;7:173-177

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