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Table of Contents
Vol. 117, No. 2, 2010
Issue release date: November 2010
Section title: Original Research
Cardiology 2010;117:105–111
(DOI:10.1159/000320216)

Viral Load and CD4+ Cell Count as Risk Factors for Prolonged QT Interval in HIV-Infected Subjects: A Cohort-Nested Case-Control Study in an Outpatient Population

QaQa A.Y. · Shaaban H. · DeBari V.A. · Phung S. · Slim J. · Costeas C.A. · Perez G. · Shamoon F.E.
Departments of aInternal Medicine, bInfectious Disease and cCardiology, St. Michaels Medical Center, School of Health and Medical Sciences, Seton Hall University, Newark, N.J., and dDepartment of Internal Medicine, School of Health and Medical Sciences, Seton Hall University, South Orange, N.J., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 5/26/2010
Accepted: 8/6/2010
Published online: 10/21/2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Background: QTc interval prolongation is a serious ECG finding which has frequently been reported in HIV-infected patients, but associated risk factors have not been determined in this population. Methods: Data were collected from the charts of a cohort of 135 consecutive HIV-infected patients from our HIV outpatient clinic. The cohort was divided into two groups, patients with prolonged QTc and those with normal QTc interval. Multiple variables and potential risk factors were analyzed, including the CD4+ cell count and viral load (VL), which were assessed on the same day or within several days of the initial ECG. Results: 23 patients were found to have prolonged QTc (17%). No significant difference in baseline characteristics was observed between the groups; however, statistically significant differences were observed with regard to the CD4+ cell count and VL. Conclusion: A low CD4 cell count and a high VL may be risk factors potentially related to QT prolongation in HIV patients in the outpatient setting.


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 5/26/2010
Accepted: 8/6/2010
Published online: 10/21/2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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