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Vol. 19, No. 6, 2010
Issue release date: September 2010
Section title: Case Report
Open Access Gateway
Med Princ Pract 2010;19:485–489
(DOI:10.1159/000320309)

Brugada Syndrome with Aborted Sudden Cardiac Death Related to Liquorice-Induced Hypokalemia

Yorgun H.a · Aksoy H.a · Şendur M.A.b · Ateş A.H.a · Kaya E.B.a · Aytemir K.a · Oto A.a
Departments of aCardiology and bInternal Medicine, Hacettepe University, Ankara, Turkey
email Corresponding Author

Hikmet Yorgun, MD

Department of Cardiology

Hacettepe University Faculty of Medicine

TR–06100 Sıhhıye, Ankara (Turkey)

Tel. +90 312 305 1780, Fax +90 312 305 4137, E-Mail yorgunhikmet@yahoo.com


References

  1. Brugada P: Brugada syndrome: an electrocardiographic diagnosis not to be missed. Heart 2000;84:1–2.
  2. Araki T, Konno T, Itoh H, Ino H, Shimizu M: Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia. Circ J 2003;67:93–95.
  3. Veltmann C, Borggrefe M, Schimpf R, Wolpert C: Images in cardiovascular medicine. Yew causes Brugada ECG. Circulation 2009;119:1836–1837.
  4. Rouleau F, Asfar P, Boulet S, Dube L, Dupuis JM, Alquier P, Vicor J: Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome. J Cardiovasc Electrophysiol 2001;12:61–65.
  5. Brugada P, Brugada J: Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20:1391–1396.
  6. Antzelevitch C: The Brugada syndrome: diagnostic criteria and cellular mechanisms. Eur Heart J 2001;22:356–363.
  7. Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR: Mineralocorticoid activity of liquorice: 11-beta- hydroxysteroid dehydrogenase deficiency comes of age. Lancet 1987;ii:821–824.

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  8. Sigurjonsdottir HA, Manhem K, Axelson M, Wallerstedt S: Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens 2003;17:125–131.
  9. Krähenbühl S, Hasler F, Frey BM, Frey FJ, Brenneisen R, Krapf R: Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J Clin Endocrinol Metab 1994;78:581–585.
  10. Sigurjonsdottir HA, Franzson L, Manhem K, Ragnarsson J, Sigurdsson G, Wallerstedt S: Liquorice-induced rise in blood pressure: a linear dose response relationship. J Hum Hypertens 2001;15:549–552.
  11. Clyburn EB, DiPette DJ: Hypertension induced by drugs and other substances. Semin Nephrol 1995;15:72–86.
  12. Helfant RH: Hypokalemia and arrhythmias. Am J Med 1986;80:13–22.
  13. Notarstefano P, Pratola C, Toselli T, Ferrari R: Atrial fibrillation and recurrent ventricular fibrillation during hypokalemia in Brugada syndrome. Pacing Clin Electrophysiol 2005;28:1350–1353.