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Vol. 194, No. 1, 2011
Issue release date: June 2011

A New Possible Function for Placental Pericytes

Jones C.J.P. · Desoye G.
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Abstract

The pericyte is a multifunctional cell closely associated with endothelial cells and may play a role in angiogenesis and vessel stabilisation. Re-examination of over 1,100 micrographs from archival material used to investigate ultrastructural changes in placental development and pathology has identified previously undescribed structures associated with the pericyte of the human placental terminal villus. These structures take the form of outgrowths from the main body of the cell, with a narrow neck rich in cytoplasmic filaments, terminating in swollen tips which appear to bleb off the pericyte and form electron lucent stromal vesicles. Semi-quantitative analysis indicated that these features are present in some placentae from normal, term pregnancies but are increasingly found where capillaries show abnormalities such as a failure to form sinusoids, as in pregnancies complicated by diabetes, postmaturity, rhesus incompatibility and pre-eclampsia. This blebbing is compared with similar phenomena associated with apoptosis and zeiosis and it is suggested that it may contribute to fluid homeostasis where normal mechanisms are impaired by thickening or damage to endothelial cells.



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References

  1. Abbro, L., L. Dini (2003) Common morphological features of apoptotic cell blebs. Ital J Zool 70:297–299.

    External Resources

  2. Asmussen, I. (1982a) Vascular morphology in diabetic placentas. Contrib Gynec Obstet 9:76–85.
  3. Asmussen, I. (1982b) Ultrastructure of the villi and fetal capillaries of the placentas delivered by non-smoking diabetic women (White Group D). APMIS, Section A, 90:95–101.
  4. Atencia, R., A. Asumendi, M. García-Sanz (2000) Role of cytoskeleton in apoptosis. Vitam Horm 58:267–297.
  5. Barros, L.F., T. Kanaseki, R. Sabirov, S. Morishima, J. Castro, C.X. Bittner, E. Maeno, Y. Ando-Akatsuka, Y. Okada (2003) Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency. Cell Death Differn 10:687–697.
  6. Bartel, H., W. Dec, L. Cieciura, J. Krajewski (1978) Ultrastructure of capillaries in the villi of human placenta. Folia Morphol (Warsz) 37:315–320.
  7. Benirschke, K., P. Kaufmann, R. Baergen (2006) Pathology of the Human Placenta, ed 5. New York, Springer.
  8. Bergers, G., S. Song (2005) The role of pericytes in blood-vessel formation and maintenance. Neuro-Oncol 7:452–464.
  9. Challier, J.C., M. Glatier, A. Kacemi, D. Guillaumin (1999) Pericytes of term human foeto-placental microvessels: ultrastructure and visualisation. Cell Molec Biol 45:89–100.
  10. Coleman, M.L., E.A. Sahai, M. Yeo, M. Bosch, A. Dewar, M.F. Olson (2001) Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 3:339–345.
  11. Díaz-Flores, L., R. Gutiérrez, J.F. Madrid, H. Varela, F. Valladares, E. Acosta, P. Martín-Vasallo, L. Díaz-Flores, Jr. (2009) Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 24:909–969.
  12. Fackler, O.T., R. Grosse (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181:879–884.
  13. Fox, H. (1997) Pathology of the Placenta, ed 2. London, W.B. Saunders Co. Ltd.
  14. Gerhardt, H., C. Betsholtz (2003) Endothelial-periocyte interactions in angiogenesis. Cell Tiss Res 314:15–23.
  15. Haust, M.D. (1981) Maternal diabetes mellitus – effects on the fetus and placenta; in Naeye R.L., J.M. Kissane, N. Kaufmann (eds): Perinatal Diseases. Baltimore, Williams & Wilkins, pp 201–285.
  16. Hirota, K., L. Strauss (1964) Electron microscopic observations on the human placenta in maternal diabetes. Fed Proc 23:575.
  17. Jewell, S.A., G. Bellomo, H. Thor, S. Orrenius, M. Smith (1982) Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science 217:1257–1259.
  18. Jones, C.J.P. (1976) An ultrastructural and ultrahistochemical study of the human placenta in normal and abnormal pregnancy. PhD Thesis, University of Manchester.
  19. Jones, C.J. P., G. Desoye (1993) Glycogen distribution in the capillaries of the placental villus in normal, overt and gestational diabetic pregnancy. Placenta 14:505–517.
  20. Jones, C.J.P., H. Fox (1976) An ultrastructural and ultrahistochemical study of the placenta of the diabetic woman. J Pathol 119:91–99.
  21. Jones, C.J.P., H. Fox (1978) Ultrastructure of the placenta in prolonged pregnancy. J. Path 128:173–179.
  22. Jones C.J.P., H. Fox (1980) An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta 1:61–76.
  23. Jones C.J.P., H. Fox (1981) An ultrastructural and ultrahistochemical study of the human placenta in maternal essential hypertension. Placenta 2:193–204.
  24. Jones, C.J.P., H. Fox (1991) Ultrastructure of the normal human placenta. Electron Microsc Rev 4:129–178.
  25. Kutcher, M.E., I.M. Herman (2009) The pericyte: cellular regulator of microvascular blood flow. Microvasc Res 77:235–246.
  26. Laster, S.M., J.M. Mackenzie Jr. (1996) Bleb formation and F-actin distribution during mitosis and tumor necrosis factor-induced apoptosis. Microsc Res Tech 34:272–280.
  27. Lister, U.M. (1964) Structural changes in the capillaries of human chorionic villi occurring with age. J Roy Microsc Soc 83:455–458.
  28. Lu, C., A.K. Sood (2008) Role of pericytes in angiogenesis; in Teicher, B.A., L.M. Ellis (eds): Cancer Drug Discovery and Development. Antiangiogenic Agents in Cancer Therapy. Totowa, Humana Press, pp 117–132.
  29. Marcussen, M. (1996) Induction of cell surface blebbing by increased cellular Pi concentration. Biochem J 318:955–958.
  30. Matsusaka, T. (1975) Tridimensional views of the relationship of pericytes to endothelial cells of capillaries in the human choroid and retina. J Elect Microsc 24:13–18.
  31. Okudaira, Y., K. Hirota, S. Cohen, L. Strauss (1966) Ultrastructure of the human placenta in maternal diabetes mellitus. Lab. Invest 15:910–926.
  32. Ozerdem, U., W.B. Stallcup (2003) Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis 6:241–249.
  33. Rhodin, J.A., J. Terzakis (1962) The ultrastructure of the human full-term placenta. J Ultrastruct Res 6:88–106.
  34. Selander, P. (1954) Postmature infants. Acta Paed 43:582–586.
  35. Schroeder, T.E. (1973) Cell Constriction: Contractile role of microfilaments in division and development. Amer Zool 13:949–960.
  36. Sims, D.E. (1986) The pericyte – a review. Tissue Cell 18:153–174.
  37. Strauss, L., N. Goldenberg, K. Hirota, Y. Okudaira (1965) Structure of the human placenta with observations on ultrastructure of the human chorionic villus. Birth Defects Original Article Series 1:13–26.
  38. Tilton, R.G. (1991) Capillary pericytes: perspectives and future trends. J Electron Microsc Tech 19:327–344.
  39. Vorherr, H. (1975) Placental insufficiency in relation to postterm pregnancy and fetal postmaturity. Evaluation of fetoplacental function; management of the postterm gravida. Am J Obstet Gynecol 123:67–103.
  40. Widmaier, G. (1969) Zur Ultrastruktur der menschlichen Placentazotten. Arch Gynäkol 207:513–527.
  41. Zeligs, J.D., S.H. Wollman (1977) Ultrastructure of blebbing and phagocytosis of blebs by hyperplastic thyroid epithelial cells in vivo. J Cell Biol 72:584–594.
  42. Zhang, E.G., G.J. Burton, S.K. Smith, D.S. Charnock-Jones (2002) Placental vessel adaptation during gestation and to high altitude: changes in diameter and perivascular cell coverage. Placenta. 23:751–762.


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