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Vol. 86, No. 3, 2011
Issue release date: April 2011
Urol Int 2011;86:284–289

Long-Term Efficacy of Serenoa repens Treatment in Patients with Mild and Moderate Symptomatic Benign Prostatic Hyperplasia

Sinescu I. · Geavlete P. · Multescu R. · Gangu C. · Miclea F. · Coman I. · Ioiart I. · Ambert V. · Constantin T. · Petrut B. · Feciche B.
aDepartment of Urological Surgery, Dialysis and Kidney Transplantation, Fundeni Clinical Institute, bDepartment of Urology, ‘Saint John’ Clinical Emergency Hospital, and c‘Prof. Dr.Th. Burghele’ Urology Clinical Hospital, Bucharest; dDepartment of Urology, Clinical Emergency Hospital, Timisoara; e‘Vasile Goldis’ University of Medicine, Department of Urology, Arad; fUniversity City Hospital and gOncological Institute ‘Ion Chiricuta’, Cluj, Romania

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Introduction: The study aimed to evaluate the long-term efficacy of treatment with extract of Serenoa repens (Prostamol Uno) in patients with lower urinary tract symptoms (LUTS) induced by benign prostatic hyperplasia (BPH). Patients and Methods: We studied 120 patients with mild or moderate LUTS induced by BPH, maximal urinary flow (Qmax) <15 ml with a voided volume ≧150 ml, prostate-specific antigen <4 ng/ml, and residual urinary volume <150 ml, treated daily for 24 months with one capsule of 320 mg ethanolic extract of Serenoa repens. Results: Statistically significant improvements in the International Prostate Symptom Score (5.5 points), quality of life (QoL; 1.8 points), Qmax (5.6 ml/s), International Index of Erectile Function (IIEF; 6.4 points) and reduction in residual urinary volume were observed during the study period. The mean prostate volume at 24 months was 36 ml, compared to 39.8 ml at baseline. Conclusions: Long-term treatment with 320 mg ethanolic extract of Serenoa repens proved to be efficient in reducing urinary obstruction, improving symptomatology and QoL of BPH patients. It also had a positive effect on sexual function, demonstrated by the statistically significant increase in the IIEF.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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