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Medulloblastoma with Extensive Nodularity Undergoing Post-Therapeutic Maturation to a Gangliocytoma: A Case Report and Literature Review

Chelliah D.a · Mensah Sarfo-Poku C.b · Stea B.D.c · Gardetto J.d · Zumwalt J.a
aSchool of Medicine and bSchool of Public Health, Loma Linda University, Loma Linda, Calif., and Departments of cRadiation Oncology and dPathology, University of Arizona, Tuscon, Ariz., USA Pediatr Neurosurg 2010;46:381–384 (DOI:10.1159/000322896)

Abstract

We present a report of a 12-year-old boy diagnosed with medulloblastoma at 22 months of age. A gross total resection was performed followed by adjuvant systemic chemotherapy due to his young age; however, the tumor recurred locally in the posterior fossa 7 months later. The recurrent tumor was excised and he received craniospinal radiation with a boost given to the posterior fossa followed by high-dose chemotherapy. He remained disease free for approximately 10 years without major neurologic deficit and only mild cognitive impairment. A routine follow-up MRI of the brain revealed an enhancing mass. The patient underwent surgical debulking and pathological examination revealed no residual immature medulloblastoma cells but instead mature ganglion cells, consistent with a gangliocytoma. The apparent maturation of primitive medulloblastoma cells is a rare phenomenon, which may have ensued from the long-term effects of adjuvant therapies inducing advanced cellular maturation.

 

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