Mast cells are well known for their role in allergic inflammation where, upon aggregation of the high-affinity immunoglobulin E receptor, they release mediators such as histamine that cause classical allergic symptoms. Mast cells are located in almost all tissues and are especially numerous in organs that interface with the environment. Given this strategic location and the more recent notion that they are endowed with receptors that recognize endogenous and exogenous danger signals such as pathogens, it is not surprising that they function as important cells in immune surveillance. When mast cells are activated by pathogens they modulate innate and adaptive immune responses. In allergy, infections might cause exacerbation of the allergic reaction by affecting the reactivity of mast cells. With new developments within the field of mast cell biology, we will better understand how mast cells execute their effector functions. This knowledge will also help to improve the management of allergic diseases.
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- Mast cell reactivity
- Allergic inflammation
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Dr. Gunnar P. Nilsson, Karolinska Institutet, Department of Medicine
Clinical Immunology and Allergy Unit
Karolinska Universitetssjukhuset Solna, KS L2:04
SE–171 76 Stockholm (Sweden)
Tel. +46 8 517 70 205, Fax +46 8 33 57 24, E-Mail firstname.lastname@example.org
Received: November 1, 2010
Accepted after revision: December 6, 2010
Published online: January 14, 2011
Number of Print Pages : 11
Number of Figures : 2, Number of Tables : 0, Number of References : 64
Journal of Innate Immunity
Vol. 3, No. 2, Year 2011 (Cover Date: February 2011)
Journal Editor: Herwald H. (Lund), Egesten A. (Lund)
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