Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivomodel systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg). Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation. Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations.
© 2011 S. Karger AG, Basel
- Virgin coconut oil
- Antinociceptive activity
- Anti-inflammatory activity
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Dr. Zainul Amiruddin Zakaria
Department of Biomedical Science, Faculty of Medicine and Health Sciences
Universiti Putra Malaysia
43400 UPM Serdang, Selangor (Malaysia)
Tel. +60 3 8947 2654, Fax +60 3 8943 6178, E-Mail email@example.com
Received: March 5, 2010
Accepted: October 13, 2010
Published online: March 29, 2011
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 21
Medical Principles and Practice (International Journal of the Kuwait University Health Sciences Centre)
Vol. 20, No. 3, Year 2011 (Cover Date: March 2011)
Journal Editor: Owunwanne A. (Kuwait), Benov L. (Kuwait)
ISSN: 1011-7571 (Print), eISSN: 1423-0151 (Online)
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