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Vol. 46, No. 2, 2011
Issue release date: July 2011

Canthaxanthin Retinopathy: Long-Term Observations

Hueber A. · Rosentreter A. · Severin M.
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Purpose: To describe the long-term outcome of canthaxanthin retinopathy. Methods: We identified 13 patients with small golden particles near the macular region among a group of 35 patients with known consumption of canthaxanthin somewhen between 1983 and 1988. One long-term follow-up examination was possible in 5 of 13 cases after 16–24 years. The examinations included determination of visual acuity, the Amsler grid, slit lamp examination, perimetry, electro-oculography, electroretinography, optical coherence tomography and fluorescein angiography. Results: Complete disappearance of the golden particles took approximately 20 years. The patients in our study were asymptomatic and no functional defect related to canthaxanthin could be detected. Conclusions: Ingestion of canthaxanthin causes no long-term adverse effects.

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