Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease which is often complicated by recurrent microbial superinfections. Genetically based modifications which might have an impact on the innate immune system, such as impairment of the skin barrier, modifications of pattern recognition receptors, deficiency of antimicrobial peptides, antiviral natural killer cells and plasmacytoid dendritic cells, facilitate the entry of allergens and infectious microbes into the skin, where they encounter immunocompetent cells. The micromilieu in the skin of AD patients further potentiates dysfunctions of the innate immune system, leading to a vicious circle promoting the disease. This article provides an overview of modifications of the innate immune system in AD.
© 2011 S. Karger AG, Basel
- Antimicrobial peptides
- Pathogen-associated molecular patterns
- Toll-like receptor
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Prof. Dr. Natalija Novak
Department of Dermatology and Allergy
University of Bonn
Sigmund-Freud-Strasse 25, DE–53127 Bonn (Germany)
Tel. +49 228 2871 5370, E-Mail Natalija.Novak@ukb.uni-bonn.de
Received: December 8, 2010
Accepted after revision: January 3, 2011
Published online: January 21, 2011
Number of Print Pages : 11
Number of Figures : 1, Number of Tables : 1, Number of References : 51
Journal of Innate Immunity
Vol. 3, No. 2, Year 2011 (Cover Date: February 2011)
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