Cover

Chronic Pain and Addiction

Editor(s): Clark M.R. (Baltimore, Md.) 
Treisman G.J. (Baltimore, Md.) 
Table of Contents
Vol. 30, 2011
Section title: Paper
Clark MR, Treisman GJ (eds): Chronic Pain and Addiction. Adv Psychosom Med. Basel, Karger, 2011, vol 30, pp 139–161
(DOI:10.1159/000324071)

Ketamine in Pain Management

Cohen S.P. · Liao W. · Gupta A. · Plunkett A.
aPain Management Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Md., bPain Management Division, Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia, Pa., and cDepartment of Surgery and dAnesthesia Service, Department of Surgery, Walter Reed Army Medical Center, Washington, D.C., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 4/19/2011
Cover Date: 2011

Number of Print Pages: 23
Number of Figures: 0
Number of Tables: 3

ISBN: 978-3-8055-9725-8 (Print)
eISBN: 978-3-8055-9726-5 (Online)

Abstract

Ketamine is an N-methyl-D-aspar tate receptor antagonist that has been in clinical use in the USA for over 30 years. Its ability to provide profound analgesia and amnesia while maintaining spontaneous respiration makes it an ideal medication for procedure-related pain and trauma. In the chronic pain arena, its use continues to evolve. There is strong evidence to support its short-term use for neuropathic and nociceptive pain, and conflicting evidence for preemptive analgesia. Its potential ability to prevent ‘windup’ and, possibly, ‘reboot’ aberrant neurologic pathways in neuropathic and central pain states has generated intense interest. However, the long-term use of ketamine for chronic neuropathic pain is limited by its side effect profile, and is largely anecdotal. More research is needed to better ascertain its long-term efficacy and side effects, to determine the ideal candidates for sustained treatment and to develop means of exploiting the antinociceptive properties of ketamine while minimizing the adverse effects.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 4/19/2011
Cover Date: 2011

Number of Print Pages: 23
Number of Figures: 0
Number of Tables: 3

ISBN: 978-3-8055-9725-8 (Print)
eISBN: 978-3-8055-9726-5 (Online)


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.