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Hum Hered 2011;71:59–66

Where’s the Evidence?

Vieland V.J.
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA
email Corresponding Author

 goto top of outline Key Words

  • Calibration
  • Evidence
  • Likelihood ratios
  • p values
  • Statistical inference
  • Thermodynamics
  • Thermometry

 goto top of outline Abstract

Science is in large part the art of careful measurement, and a fixed measurement scale is the sine qua non of this art. It is obvious to us that measurement devices lacking fixed units and constancy of scale across applications are problematic, yet we seem oddly laissez faire in our approach to measurement of one critically important quantity: statistical evidence. Here I reconsider problems with reliance on p values or maximum LOD scores as measures of evidence, from a measure-theoretic perspective. I argue that the lack of an absolute scale for evidence measurement is every bit as problematic for modern biological research as was lack of an absolute thermal scale in pre-thermodynamic physics. Indeed, the difficulty of establishing properly calibrated evidence measures is strikingly similar to the problem 19th century physicists faced in deriving an absolute scale for the measurement of temperature. I propose that the formal relationship between the two problems might enable us to apply the mathematical foundations of thermodynamics to establish an absolute scale for the measurement of evidence, in statistical applications and possibly other areas of mathematical modeling as well. Here I begin to sketch out what such an endeavor might look like.

Copyright © 2011 S. Karger AG, Basel

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    External Resources

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 goto top of outline Author Contacts

Veronica J. Vieland
Battelle Center for Mathematical Medicine
The Research Institute at Nationwide Children’s Hospital
700 Children’s Drive, Columbus, OH 43205 (USA)
Tel. +1 614 722 2688, E-Mail

 goto top of outline Article Information

Received: January 6, 2011
Accepted after revision: February 2, 2011
Published online: March 22, 2011
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 0, Number of References : 18

 goto top of outline Publication Details

Human Heredity (International Journal of Human and Medical Genetics)

Vol. 71, No. 1, Year 2011 (Cover Date: April 2011)

Journal Editor: Devoto M. (Philadelphia, Pa./Rome)
ISSN: 0001-5652 (Print), eISSN: 1423-0062 (Online)

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