Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be expressed in various types of cancer. To elucidate the expression of podoplanin in precancerous lesions, we examined the immunohistochemical profiles of podoplanin in oral squamous epithelial lesions. Method: We studied a total of 298 foci of squamous cell carcinoma (SCC), carcinoma in situ (CIS), epithelial dysplasia, and hyperplastic and/or normal epithelial lesions by immunohistochemistry using D2-40. Results: There was no positivity for podoplanin in normal or hyperplastic epithelia, while all of the CIS and SCC foci stained positive. Approximately one third of the mild dysplasia foci (10 of 36 foci, 28%) and 80% of moderate dysplasia foci (78/98) showed grade 1 positive reactions (positive only in the 1st layer). Grade 2 reactions (up to 4th layer) were seen in 4 of 98 moderate dysplasia foci (4%), 29 of 74 CIS foci (39%), and 3 of 30 SCC foci (10%). Grade 3 reactions (to more than 5th layer) were found in 35 (47%) CIS foci and 26 (87%) SCC foci. Conclusions: The relationship between the present histological categorization and podoplanin grade was statistically significant. D2-40 expression is considered to be related to the severity of oral precancerous lesions.
© 2011 S. Karger AG, Basel
- Carcinoma in situ
- Epithelial dysplasia
- Oral mucosa
- Squamous cell carcinoma
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Prof. Takashi Saku
Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction
Niigata University Graduate School of Medical and Dental Sciences
2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514 (Japan)
Tel. +81 25 227 2832, E-Mail firstname.lastname@example.org
Received: November 11, 2010
Accepted after revision: February 8, 2011
Published online: May 26, 2011
Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 1, Number of References : 26
Pathobiology (Exploring the basis of disease)
Vol. 78, No. 3, Year 2011 (Cover Date: June 2011)
Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015-2008 (Print), eISSN: 1423-0291 (Online)
For additional information: http://www.karger.com/PAT
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