Cover

Fluoride and the Oral Environment

Editor(s): Buzalaf M.A.R. (Bauru) 
Table of Contents
Vol. 22, 2011
Section title: Impact of Fluoride in the Prevention of Caries and Erosion
Buzalaf MAR (ed): Fluoride and the Oral Environment. Monogr Oral Sci. Basel, Karger, 2011, vol 22, pp 97–114
(DOI:10.1159/000325151)

Mechanisms of Action of Fluoride for Caries Control

Buzalaf M.A.R. · Pessan J.P. · Honório H.M. · ten Cate J.M.
aDepartment of Biological Sciences and bDepartment of Pediatric Dentistry, Orthodontics and Public Health, Bauru Dental School, University of São Paulo, Bauru, and cDepartment of Pediatric Dentistry and Public Health, Araçatuba Dental School, São Paulo State University, Araçatuba, Brazil; dDepartment of Cariology, Endodontology and Pedodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Impact of Fluoride in the Prevention of Caries and Erosion

Published online: 6/23/2011
Cover Date: 2011

Number of Print Pages: 18
Number of Figures: 11
Number of Tables: 1

ISBN: 978-3-8055-9658-9 (Print)
eISBN: 978-3-8055-9659-6 (Online)

Abstract

Fluoride was introduced into dentistry over 70 years ago, and it is now recognized as the main factor responsible for the dramatic decline in caries prevalence that has been observed worldwide. However, excessive fluoride intake during the period of tooth development can cause dental fluorosis. In order that the maximum benefits of fluoride for caries control can be achieved with the minimum risk of side effects, it is necessary to have a profound understanding of the mechanisms by which fluoride promotes caries control. In the 1980s, it was established that fluoride controls caries mainly through its topical effect. Fluoride present in low, sustained concentrations (sub-ppm range) in the oral fluids during an acidic challenge is able to absorb to the surface of the apatite crystals, inhibiting demineralization. When the pH is re-established, traces of fluoride in solution will make it highly supersaturated with respect to fluorhydroxyapatite, which will speed up the process of remineralization. The mineral formed under the nucleating action of the partially dissolved minerals will then preferentially include fluoride and exclude carbonate, rendering the enamel more resistant to future acidic challenges. Topical fluoride can also provide antimicrobial action. Fluoride concentrations as found in dental plaque have biological activity on critical virulence factors of S. mutans in vitro, such as acid production and glucan synthesis, but the in vivo implications of this are still not clear. Evidence also supports fluoride’s systemic mechanism of caries inhibition in pit and fissure surfaces of permanent first molars when it is incorporated into these teeth pre-eruptively.


Article / Publication Details

First-Page Preview
Abstract of Impact of Fluoride in the Prevention of Caries and Erosion

Published online: 6/23/2011
Cover Date: 2011

Number of Print Pages: 18
Number of Figures: 11
Number of Tables: 1

ISBN: 978-3-8055-9658-9 (Print)
eISBN: 978-3-8055-9659-6 (Online)


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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