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Vol. 32, No. 2, 2011
Issue release date: August 2011
Section title: Original Paper
Blood Purif 2011;32:144–149
(DOI:10.1159/000325222)

Hepatitis C Virus Adversely Affects Quality of Life

Cillo U. · Amodio P. · Ronco C. · Soni S.S. · Zanus G. · Minazzato L. · Salari A. · Neri D. · Bombonato G. · Schiff S. · Bianco T.
aUO Operative Unit of Hepatobiliary Surgery, bDepartment of Clinical and Experimental Medicine and cAntalgic Therapy, Institute of Anesthesiology and Reanimation, University of Padua, Padua, and dDepartment of Nephrology, Ospedale San Bortolo, Vicenza, Italy; eDepartment of Nephrology, Manik Hospital and Research Centre, and MGM Medical College, Aurangabad, India

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/4/2011
Accepted: 2/8/2011
Published online: 6/10/2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 3

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

Background: Chronic liver disease secondary to hepatitis C virus (HCV) infection is a common clinical problem. HCV is likely to adversely affect the quality of life (QoL) of the patient. This effect is said to be disproportionate to the severity of the disease. The aim of our study was to evaluate QoL in HCV-positive patients focusing both on health status and subjective satisfaction. Methods: Twenty-four patients with combined HCV and alcoholic liver disease (ETOH-HCV) were enrolled in the study. We adopted two generic tools: SF-36 (a health status questionnaire) and SAT-P (a satisfaction profile) for psychological assessment of the patients. SF-36 and SAT-P scores of ETOH-HCV patients were compared with scores of 23 patients with alcoholic liver disease (ETOH). The scores obtained from the study groups were also compared with the reference scores of the healthy Italian population. Results: Both the groups were comparable with respect to age, histological and clinical severity of liver disease (as assessed by MELD and Child Pugh scores). Patients with ETOH-HCV scored less in the vitality and role emotional status domains of the SF-36 scores and the psychological function, social function and free time domains of the satisfaction profile. Conclusions: These results show a significant impact of HCV infection on health status and subjective satisfaction.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/4/2011
Accepted: 2/8/2011
Published online: 6/10/2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 3

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

  1. Apolone Giovanni MP, Ware J Jr: Questionario sullo stato di salute sf-36. Manuale d’uso e guida all’interpretazione dei risultati, 2000, vol 9, p 227.
  2. Majani GCS, Pierobon A: A new instrument in quality of life assessment: the satisfaction profile (Sat-P). Int J Ment Health 1999;28:77–82.
  3. Foster GR: Quality of life considerations for patients with chronic hepatitis C. J Viral Hepat 2009;16:605–611.
  4. Marcellin P: Hepatitis C: the clinical spectrum of the disease. J Hepatol 1999;31(suppl 1):9–16.
  5. El-Serag HB, Mason AC: Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med 2000;160:3227–3230.
  6. Tong MJ, el-Farra NS, Reikes AR, Co RL: Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 1995;332:1463–1466.
  7. Kenny-Walsh E: Clinical outcomes after hepatitis C infection from contaminated anti-d immune globulin: Irish Hepatology Research Group. N Engl J Med 1999;340:1228–1233.
  8. Barkhuizen A, Rosen HR, Wolf S, Flora K, Benner K, Bennett RM: Musculoskeletal pain and fatigue are associated with chronic hepatitis C: a report of 239 hepatology clinic patients. Am J Gastroenterol 1999;94:1355–1360.
  9. Abdo AA: Hepatitis C and poor quality of life: Is it the virus or the patient? Saudi J Gastroenterol 2008;14:109–113.
  10. Poynard T, Cacoub P, Ratziu V, Myers RP, Dezailles MH, Mercadier A, Ghillani P, Charlotte F, Piette JC, Moussalli J: Fatigue in patients with chronic hepatitis C. J Viral Hepat 2002;9:295–303.
  11. Rodger AJ, Jolley D, Thompson SC, Lanigan A, Crofts N: The impact of diagnosis of hepatitis C virus on quality of life. Hepatology 1999;30:1299–1301.
  12. Forton DM, Thomas HC, Taylor-Robinson SD: Central nervous system involvement in hepatitis C virus infection. Metab Brain Dis 2004;19:383–391.
  13. Forton DM, Hamilton G, Allsop JM, Grover VP, Wesnes K, O’Sullivan C, Thomas HC, Taylor-Robinson SD: Cerebral immune activation in chronic hepatitis C infection: a magnetic resonance spectroscopy study. J Hepatol 2008;49:316–322.
  14. Bagaglio S, Cinque P, Racca S, Pedale R, Grasso MA, Lazzarin A, Morsica G: Hepatitis c virus populations in the plasma, peripheral blood mononuclear cells and cerebrospinal fluid of HIV/hepatitis C virus-co-infected patients. AIDS 2005;19(suppl 3): S151–165.
  15. Ware JE Jr: Sf-36 health survey update. Spine 2000;25:3130–3139.
  16. Strauss E, Dias Teixeira MC: Quality of life in hepatitis C. Liver Int 2006;26:755–765.
  17. Spiegel BM, Younossi ZM, Hays RD, Revicki D, Robbins S, Kanwal F: Impact of hepatitis c on health related quality of life: a systematic review and quantitative assessment. Hepatology 2005;41:790–800.