Cover

Milk and Milk Products in Human Nutrition

67th Nestlé Nutrition Institute Workshop, Pediatric Program, Marrakech, March 2010

Editor(s): Clemens R.A. (Los Angeles, Calif.) 
Hernell O. (Umeå) 
Michaelsen K.F. (Copenhagen) 
Table of Contents
Vol. 67, No. , 2011
Section title: Milk during Childhood in Low- and High-Income Countries
Clemens RA, Hernell O, Michaelsen KF (eds): Milk and Milk Products in Human Nutrition. Nestlé Nutr Inst Workshop Ser Pediatr Program, vol 67, pp 131–145, Nestec Ltd., Vevey/S. Karger AG, Basel, © 2011
(DOI:10.1159/000325580)

Evidence for Acne-Promoting Effects of Milk and Other Insulinotropic Dairy Products

Melnik B.C.
Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany

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Article / Publication Details

First-Page Preview
Abstract of Milk during Childhood in Low- and High-Income Countries

Published online: 2/16/2011
Cover Date: 2011

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9586-5 (Print)
eISBN: 978-3-8055-9587-2 (Online)

Abstract

Acne vulgaris, the most common skin disease of western civilization, has evolved to an epidemic affecting more than 85% of adolescents. Acne can be regarded as an indicator disease of exaggerated insulinotropic western nutrition. Especially milk and whey protein-based products contribute to elevations of postprandial insulin and basal insulin-like growth factor-I (IGF-I) plasma levels. It is the evolutional principle of mammalian milk to promote growth and support anabolic conditions for the neonate during the nursing period. Whey proteins are most potent inducers of glucose-dependent insulinotropic polypeptide secreted by enteroendocrine K cells which in concert with hydrolyzed whey protein-derived essential amino acids stimulate insulin secretion of pancreatic β-cells. Increased insulin/IGF-I signaling activates the phosphoinositide-3 kinase/Akt pathway, thereby reducing the nuclear content of the transcription factor FoxO1, the key nutrigenomic regulator of acne target genes. Nuclear FoxO1 deficiency has been linked to all major factors of acne pathogenesis, i.e. androgen receptor transactivation, comedogenesis, increased sebaceous lipogenesis, and follicular inflammation. The elimination of the whey protein-based insulinotropic mechanisms of milk will be the most important future challenge for nutrition research. Both, restriction of milk consumption or generation of less insulinotropic milk will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne.


Article / Publication Details

First-Page Preview
Abstract of Milk during Childhood in Low- and High-Income Countries

Published online: 2/16/2011
Cover Date: 2011

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9586-5 (Print)
eISBN: 978-3-8055-9587-2 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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