Eosinophilic Gastrointestinal Disorders in Infants: A Japanese Case SeriesYamada Y. · Nishi A. · Ebara Y. · Kato M. · Yamamoto H. · Morita H. · Nomura I. · Matsumoto K. · Hirato J. · Hatakeyama S. · Suzuki N. · Hayashi Y.
Divisions of aAllergy and Immunology, bSurgery, cGeneral Medicine, dRadiology and eHematology and Oncology, Gunma Children’s Medical Center, Shibukawa, fDivision of Pediatrics, National Hospital Organization, Takasaki General Medical Center, Takasaki, gDepartment of Allergy and Immunology, National Research Institute for Child Health and Development, hDepartment of Pediatrics, Keio University School of Medicine, and iDivision of Allergy, National Center for Child Health and Development, Tokyo, and jDepartment of Pathology, Gunma University Hospital, Maebashi, Japan
Background: Eosinophilic gastrointestinal disorders (EGIDs) are disorders characterized by primary eosinophil inflammation in the gastrointestinal tract. There are a small number of reports of eosinophil infiltration in gastrointestinal tracts presenting as EGIDs in infants. In this study, we present Japanese cases of EGIDs in infants. Methods: Five patients diagnosed with or strongly suspected to have EGIDs in our hospital from 2008 to 2010 were reviewed. Radiographic contrast enema examinations and/or endoscopies were performed in 4 and 3 patients, respectively. Results: There were patients with eosinophilic colitis (1 suspected and 2 biopsy-proven), a patient who was suspected of having allergic eosinophilic enterocolitis, and a patient with eosinophilic gastroenteritis associated with pediatric hypereosinophilic syndrome. Conclusions: The causes and clinical findings of patients with intestinal eosinophil inflammation vary. Therefore, deliberate examination and observation are important for patients with infantile EGID.