Cover

Hemodialysis

New Methods and Future Technology

Editor(s): Ronco C. (Vicenza) 
Rosner M.H. (Charlottesville, Va.) 
Table of Contents
Vol. 171, 2011
Section title: Lipid Disorders and Metabolism
Ronco C, Rosner MH (eds): Hemodialysis: New Methods and Future Technology. Contrib Nephrol. Basel, Karger, 2011, vol 171, pp 135–142
(DOI:10.1159/000327317)

Lipid Abnormalities in Patients with Chronic Kidney Disease

Keane W.F. · Tomassini J.E. · Neff D.R.
aUniversity of Minnesota School of Medicine, and bMerck Sharp & Dohme Corp., Whitehouse Station, N.J., USA

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Article / Publication Details

First-Page Preview
Abstract of Lipid Disorders and Metabolism

Published online: 5/23/2011
Cover Date: 2011

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 1

ISBN: 978-3-8055-9771-5 (Print)
eISBN: 978-3-8055-9772-2 (Online)

Abstract

Cardiovascular disease is increased in patients with chronic kidney disease (CKD) and is the principle cause of morbidity and mortality in these patients. Dyslipidemia, while common in these patients, is usually not characterized by elevated cholesterol, except in those patients with massive proteinuria. Qualitatively, increased triglycerides and reduced high-density lipoproteins (HDL) are most frequently described. Extensive abnormalities in the metabolism of apolipoprotein (apo) B-containing lipoproteins have been demonstrated, including those derived from the gut (apoB-48) as well as those derived from hepatic synthesis (apoB-100). Decreased enzymatic delipidation, in addition to reduced receptor removal of these lipoproteins, results in increased concentrations of these apoB-containing moieties, and in particular, their atherogenic remnants. Abnormalities in apoA-containing lipoproteins are also present and these changes may contribute not only to the lower levels of HDL seen, but also to the proinflammatory state that is frequently present in CKD patients. As a result, therapeutic strategies designed to modify atherosclerotic-caused outcomes in CKD may require multiple approaches.


Article / Publication Details

First-Page Preview
Abstract of Lipid Disorders and Metabolism

Published online: 5/23/2011
Cover Date: 2011

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 1

ISBN: 978-3-8055-9771-5 (Print)
eISBN: 978-3-8055-9772-2 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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