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Table of Contents
Vol. 24, No. 6, 2011
Issue release date: September 2011
Section title: Original Paper
Skin Pharmacol Physiol 2011;24:322–329
(DOI:10.1159/000328744)

Epidermal Barrier Treatments Based on Vernix Caseosa

Visscher M.O. · Barai N. · LaRuffa A.A. · Pickens W.L. · Narendran V. · Hoath S.B.
aSkin Sciences Institute, Division of Neonatology and Pulmonary Biology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, and bJames L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/2/2010 3:28:10 PM
Accepted: 3/22/2011
Published online: 8/4/2011

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Background/Aims: Premature infants lack the vernix caseosa, have an incompetent stratum corneum (SC) barrier and are predisposed to infection. Use of topical agents to improve barrier function has had mixed outcomes. The aim was to determine the effect of vernix versus common barrier creams on the rate and quality of the epidermal barrier repair following controlled wounding. Methods: Minor wounds were created with (1) laser ablation in the minipig and (2) tape stripping of mother’s volar skin as a model for premature skin. Native vernix was applied to the mother’s tape-stripped skin. Treatments were no occlusion (NO), vernix and a petrolatum-based cream (PBC) in the pig, and NO, vernix, PBC, an oil-in-water cream (OWC), a semipermeable film (SP) and full occlusion (FO) in adults. Results: Outcomes for both trials were barrier recovery and skin hydration (moisture accumulation rate, MAT), initial hydration, erythema and dryness in adults. Vernix and PBC produced greater barrier repair than NO in the pig. SP produced greater recovery than NO and FO in adults. Vernix yielded greater recovery than FO and was similar to PBC, OWC and NO. Vernix had a directionally higher MAT than OWC and directionally higher initial hydration than NO. Conclusions: The findings suggest that vernix-based topical creams would be effective for the treatment of epidermal wounds and show promise to augment SC repair and maturation in infants.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/2/2010 3:28:10 PM
Accepted: 3/22/2011
Published online: 8/4/2011

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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