It has been much debated how the Drosophila immune system can recognize bacterial peptidoglycan that is often hidden. We show that bacteria separated from Drosophila S2 cells by a semipermeable membrane can upregulate the Imd pathway. Supernatants from exponentially growing but not from stationary-phase bacterial cultures induce antimicrobial peptides. It is also made likely that the shed elicitors are of peptidoglycan nature.
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Dr. Håkan Steiner
Department of Genetics, Microbiology and Toxicology
SE–106 91 Stockholm (Sweden)
Tel. +46 8 164 161, E-Mail firstname.lastname@example.org
Received: December 21, 2010
Accepted after revision: May 10, 2011
Published online: August 9, 2011
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 0, Number of References : 23
Journal of Innate Immunity
Vol. 4, No. 1, Year 2012 (Cover Date: December 2011)
Journal Editor: Herwald H. (Lund), Egesten A. (Lund)
ISSN: 1662-811X (Print), eISSN: 1662-8128 (Online)
For additional information: http://www.karger.com/JIN
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