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Vol. 37, No. 1, 2011
Issue release date: September 2011
Section title: Original Paper
Neuroepidemiology 2011;37:52–57
(DOI:10.1159/000329258)

Sun Exposure, Vitamin D Intake and Progression to Disability among Veterans with Progressive Multiple Sclerosis

McDowell T.-Y. · Amr S. · Culpepper W.J. · Langenberg P. · Royal W. · Bever C. · Bradham D.D.
aMS Center of Excellence–East, Baltimore VAMC, Departments of bEpidemiology and Public Health and cNeurology, University of Maryland, Baltimore School of Medicine, and dDepartment of Pharmaceutical Health Services Research, University of Maryland, Baltimore School of Pharmacy, Baltimore, Md., and eDepartment of Preventive Medicine and Public Health, University of Kansas, School of Medicine–Wichita, Wichita, Kans., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/13/2010
Accepted: 5/11/2011
Published online: 8/5/2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: Early life events have been suggested to influence multiple sclerosis (MS) susceptibility, and to potentially modulate its clinical course. We assessed vitamin D-related exposures from childhood to disease onset and their associations with MS progression. Methods: Among veterans in the Multiple Sclerosis Surveillance Registry, 219 reported having the progressive form and met the inclusion criteria. Participants reported their past sun exposure, vitamin D-related intake and age at disability milestones using the Patient-Determined Disease Steps (PDDS). The Cox proportional hazards model was used to examine the association between vitamin D-related exposures and time (years) to disability. Results: Low average sun exposure in the fall/winter before disease onset was associated with an increased risk of progressing to a PDDS score of 8 (hazard ratio, HR: 2.13, 95% confidence interval, CI: 1.20–3.78), whereas use of cod liver oil during childhood and adolescence was associated with a reduced risk (HR: 0.44, 95% CI: 0.20–0.96). Conclusions: These results suggest that exposure to vitamin D before MS onset might slow disease-related neurodegeneration and thus delay progression to disability among patients with the progressive subtype.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/13/2010
Accepted: 5/11/2011
Published online: 8/5/2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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